Neuroplasticity and psychiatry

Gynther, BD, Calford, MB and Sah, P (1998) Neuroplasticity and psychiatry. Australian And New Zealand Journal of Psychiatry, 32 1: 119-128. doi:10.3109/00048679809062718

Author Gynther, BD
Calford, MB
Sah, P
Title Neuroplasticity and psychiatry
Journal name Australian And New Zealand Journal of Psychiatry   Check publisher's open access policy
ISSN 0004-8674
Publication date 1998-01-01
Sub-type Article (original research)
DOI 10.3109/00048679809062718
Open Access Status Not Open Access
Volume 32
Issue 1
Start page 119
End page 128
Total pages 10
Language eng
Abstract Objective: There is increasing concern that the course of psychiatric disorders may be affected by parameters such as the duration and intensity of symptoms of initial episodes of illness. As this indicates that abnormal function produces long-term changes within the brain, a review of the neuroscience literature regarding neuroplasticity is warranted. Method: This article is a selective review, focusing in particular on results obtained from physiological experiments assessing plasticity within the mammalian neocortex. The possible relevance of results to psychiatry is discussed. Results: While the most dramatic examples of neuroplasticity occur during a critical period of neural development, neuroplasticity can also occur in adult neocortex. Neuroplasticity appears to be activity-dependent: synaptic pathways that are intensively used may become strengthened, and conversely, there may be depression of transmission in infrequently used pathways. Conclusions: Results from neurophysiological experiments fend support to the clinical observation that the intensity and duration of a psychiatric disorder may adversely alter its long-term course. Rapid aggressive treatment may prevent this from occurring. While pharmacotherapy may reduce the duration and severity of symptoms, it may also have an independent, as yet unknown, effect on neuroplasticity.
Keyword Psychiatry
Long-term Potentiation
Sensory Cortex
Long-term Potentiation
Inhibitory Synaptic Transmission
Frequency-discrimination Task
Cortical Reorganization
Nmda Receptors
Adult Monkeys
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 13 Aug 2007, 20:22:36 EST