Diffusion MR microscopy of cortical development in the mouse embryo

Aggarwal, Manisha, Gobius, Ilan, Richards, Linda J. and Mori, Susumu (2014) Diffusion MR microscopy of cortical development in the mouse embryo. Cerebral Cortex, 25 7: 1970-1980. doi:10.1093/cercor/bhu006

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Author Aggarwal, Manisha
Gobius, Ilan
Richards, Linda J.
Mori, Susumu
Title Diffusion MR microscopy of cortical development in the mouse embryo
Journal name Cerebral Cortex   Check publisher's open access policy
ISSN 1460-2199
1047-3211
Publication date 2014-02-10
Year available 2015
Sub-type Article (original research)
DOI 10.1093/cercor/bhu006
Open Access Status File (Author Post-print)
Volume 25
Issue 7
Start page 1970
End page 1980
Total pages 11
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Abstract Cortical development in the mouse embryo involves complex changes in the microstructure of the telencephalic wall, which are challenging to examine using three-dimensional (3D) imaging techniques. In this study, high-resolution 3D diffusion magnetic resonance (dMR) microscopy of the embryonic mouse cortex is presented. Using diffusion-weighted gradient- and spin-echo based acquisition, dMR microimaging data were acquired from fixed mouse embryos at 7 developmental stages from embryonic day (E)12.5 to E18.5. The dMR imaging (dMRI) contrasts revealed microscopic structural detail in the mouse telencephalic wall, allowing delineation of transient zones in the developing cortex based on their unique diffusion signatures. With the high-resolution 3D data of the mouse embryo, we were able to visualize the complex microstructure of embryonic cerebral tissue and to resolve its regional and temporal evolution during cortical formation. Furthermore, averaged dMRI contrasts generated via deformable registration revealed distinct spatial and temporal gradients of anisotropy variation across the developing embryonic cortical plate and the ventricular zone. The findings of this study demonstrate the potential of 3D dMRI to resolve the complex microstructure of the embryonic mouse cortex, and will be important for investigations of corticogenesis and its disruption in embryonic mouse models.
Keyword Cortex
Development
Diffusion MRI
Microimaging
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID R01AG020012
APP1043045
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2015 Collection
School of Biomedical Sciences Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 10 Dec 2014, 22:49:23 EST by Debra McMurtrie on behalf of Queensland Brain Institute