Is the soleus a sentinel muscle for impaired aerobic capacity in heart failure?

Panizzolo, Faustio A., Maiorana, Andrew J., Naylor, Louise H., Lichtwark, Glen A., Dembo, Lawrence, Lloyd, David G., Green, Daniel J. and Rubenson, Jonas (2015) Is the soleus a sentinel muscle for impaired aerobic capacity in heart failure?. Medicine and Science in Sports and Exercise, 47 3: 498-508. doi:10.1249/MSS.0000000000000431


Author Panizzolo, Faustio A.
Maiorana, Andrew J.
Naylor, Louise H.
Lichtwark, Glen A.
Dembo, Lawrence
Lloyd, David G.
Green, Daniel J.
Rubenson, Jonas
Title Is the soleus a sentinel muscle for impaired aerobic capacity in heart failure?
Journal name Medicine and Science in Sports and Exercise   Check publisher's open access policy
ISSN 0195-9131
1530-0315
Publication date 2015-03-01
Year available 2014
Sub-type Article (original research)
DOI 10.1249/MSS.0000000000000431
Volume 47
Issue 3
Start page 498
End page 508
Total pages 11
Place of publication Philadelphia United States
Publisher Lippincott Williams & Wilkins
Collection year 2015
Language eng
Abstract PURPOSE: Skeletal muscle wasting is well documented in chronic heart failure (CHF). This paper provides a more detailed understanding of the morphology behind this muscle wasting and the relationship between muscle morphology, strength and exercise capacity in CHF. We investigated the impact of CHF on lower limb lean mass, detailed muscle-tendon architecture of the individual triceps surae muscles (soleus, SOL; medial gastrocnemius, MG and lateral gastrocnemius, LG) and how these parameters relate to exercise capacity and strength. METHODS: 11 CHF patients and 15 age-matched controls were recruited. Lower limb lean mass was assessed by dual energy X-ray absorptiometry (DXA) and the architecture of skeletal muscle and tendon properties by ultrasound. Plantarflexor strength was assessed by dynamometry. RESULTS: Patients with CHF exhibited ∼25% lower combined triceps surae volume and physiological cross-sectional area (PCSA) compared to control subjects (p < 0.05), driven in large part by reductions in the SOL. Only the SOL volume and the SOL and MG PCSA were statistically different between groups after normalizing to lean body mass and body surface area, respectively. Total lower limb lean mass did not differ between CHF and control subjects, further highlighting the SOL specificity of muscle wasting in CHF. Moreover, the volume of the SOL and plantarflexor strength correlated strongly with peak oxygen uptake (V ̇O2 peak) in patients with CHF. CONCLUSIONS: These findings suggest that the SOL may be a sentinel skeletal muscle in CHF and provide a rationale for including plantarflexor muscle training in CHF care.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Human Movement and Nutrition Sciences Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 6 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 09 Dec 2014, 20:15:49 EST by Ms Kate Rowe on behalf of Scholarly Communication and Digitisation Service