Vestibular and visual responses in human posterior insular cortex

Frank, Sebastian M., Baumann, Oliver, Mattingley, Jason B. and Greenlee, Mark W. (2014) Vestibular and visual responses in human posterior insular cortex. Journal of Neurophysiology, 112 10: 2481-2491. doi:10.1152/jn.00078.2014


Author Frank, Sebastian M.
Baumann, Oliver
Mattingley, Jason B.
Greenlee, Mark W.
Title Vestibular and visual responses in human posterior insular cortex
Journal name Journal of Neurophysiology   Check publisher's open access policy
ISSN 1522-1598
0022-3077
Publication date 2014-11-15
Year available 2014
Sub-type Article (original research)
DOI 10.1152/jn.00078.2014
Open Access Status DOI
Volume 112
Issue 10
Start page 2481
End page 2491
Total pages 11
Place of publication Bethesda, MD, United States
Publisher American Physiological Society
Language eng
Abstract The central hub of the cortical vestibular network in humans is likely localized in the region of posterior lateral sulcus. An area characterized by responsiveness to visual motion has previously been described at a similar location and named posterior insular cortex (PIC). Currently it is not known whether PIC processes vestibular information as well. We localized PIC using visual motion stimulation in functional magnetic resonance imaging (fMRI) and investigated whether PIC also responds to vestibular stimuli. To this end, we designed an MRI-compatible caloric stimulation device that allowed us to stimulate bithermally with hot temperature in one ear and simultaneously cold temperature in the other or with warm temperatures in both ears for baseline. During each trial, participants indicated the presence or absence of self-motion sensations. We found activation in PIC during periods of self motion when vestibular stimulation was carried out with minimal visual input. In combined visual-vestibular stimulation area PIC was activated in a similar fashion during congruent and incongruent stimulation conditions. Our results show that PIC not only responds to visual motion but also to vestibular stimuli related to the sensation of self motion. We suggest that PIC is part of the cortical vestibular network and plays a role in the integration of visual and vestibular stimuli for the perception of self motion.
Keyword Caloric stimulation
fMRI
Multisensory integration
Posterior insular cortex
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2015 Collection
 
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