Cognitive and structural neuroimaging characteristics of schizophrenia patients with large, rare copy number deletions

Martin, Andrew Kenneth, Robinson, Gail, Reutens, David and Mowry, Bryan (2014) Cognitive and structural neuroimaging characteristics of schizophrenia patients with large, rare copy number deletions. Psychiatry Research: Neuroimaging, 224 3: 311-318. doi:10.1016/j.pscychresns.2014.10.006

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ346582_OA.pdf Full text (open access) application/pdf 942.04KB 0

Author Martin, Andrew Kenneth
Robinson, Gail
Reutens, David
Mowry, Bryan
Title Cognitive and structural neuroimaging characteristics of schizophrenia patients with large, rare copy number deletions
Journal name Psychiatry Research: Neuroimaging   Check publisher's open access policy
ISSN 0925-4927
1872-7506
Publication date 2014-12-30
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.pscychresns.2014.10.006
Volume 224
Issue 3
Start page 311
End page 318
Total pages 8
Place of publication Shannon, County Clare, Ireland
Publisher Elsevier Ireland
Language eng
Formatted abstract
Large (>500 Kb), rare (frequency <1%) deletions are associated with risk for schizophrenia. The aim of the study was to characterise patients with these deletions using measures of cognition, grey-matter volume and white-matter integrity. Patients with schizophrenia and large, rare deletions (SZ-del) (n=17) were assessed on a test of intelligence, the Wechsler Abbreviated Scale of Intelligence (WASI), and compared with age- and sex-matched schizophrenia patients without large, rare deletions (SZ-nodel) (n=65), and healthy controls (HCs) (n=50). Regional grey-matter differences were investigated using voxel-based morphometry (SZ-del=9; SZ-nodel=26; HC=19). White-matter integrity was assessed using fractional anisotropy (SZ-del=9; SZ-nodel=24; HC=15). Compared with schizophrenia patients without large, rare deletions, those with large, rare deletions had lower IQ; greater grey-matter volume in clusters with peaks in the left and right cerebellum, left hippocampus, and right rectal gyrus; and increased white-matter anisotropy in the body and genu of the corpus callosum. Compared with healthy controls, patients with large, rare deletions had reduced grey matter volume in the right calcarine gyrus. In sum, patients with large, rare deletions had structural profiles intermediate to those observed in healthy controls and schizophrenia patients without large, rare deletions, but had greater impairment in intelligence.
Keyword Schizophrenia
Cognition
Deletions
Copy number variants
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 3 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 05 Dec 2014, 11:50:20 EST by Gail Robinson on behalf of School of Psychology