Long-term potentiation of synaptic transmission in the avian hippocampus

Margrie, TW, Rostas, JAP and Sah, P (1998) Long-term potentiation of synaptic transmission in the avian hippocampus. Journal of Neuroscience, 18 4: 1207-1216.

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Author Margrie, TW
Rostas, JAP
Sah, P
Title Long-term potentiation of synaptic transmission in the avian hippocampus
Journal name Journal of Neuroscience   Check publisher's open access policy
ISSN 0270-6474
Publication date 1998-01-01
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 18
Issue 4
Start page 1207
End page 1216
Total pages 10
Language eng
Abstract The avian hippocampus plays a pivotal role in memory required for spatial navigation and food storing. Here we have examined synaptic transmission and plasticity within the hippocampal formation of the domestic chicken using an in vitro slice preparation. With the use of sharp microelectrodes we have shown that excitatory synaptic inputs in this structure are glutamatergic and activate both NMDA-and AMPA-type receptors on the postsynaptic membrane. In response to tetanic stimulation, the EPSP displayed a robust long-term potentiation (LTP) lasting >1 hr. This LTP was unaffected by blockade of NMDA receptors or chelation of postsynaptic calcium. Application of forskolin increased the EPSP and reduced paired-pulse facilitation: (PPF), indicating an increase in release probability. In contrast, LTP was not associated with a change in the PPF ratio. Induction of LTP did not occlude the effects of forskolin. Thus, in contrast to NMDA receptor-independent LTP in the mammalian brain, LTP in the chicken hippocampus is not attributable to a change in the probability of transmitter release and does not require activation of adenylyl cyclase, These findings indicate that a novel form of synaptic plasticity might underlie learning in the avian hippocampus.
Keyword Neurosciences
Calcium
Plasticity
Nmda
Memory
Forskolin
Ppf
Camp
Crayfish Neuromuscular-junction
Pigeon Columba-livia
Dorsomedial Telencephalon
Excitatory Synapses
Homing Pigeons
2 Forms
Memory
Plasticity
Neurons
Lesions
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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Created: Mon, 13 Aug 2007, 20:20:00 EST