Chronic ingestion of a Western diet increases O-linked-β-N-acetylglucosamine (O-GlcNAc) protein modification in the rat heart

Medford, H. M., Chatham, J. C. and Marsh, S. A. (2012) Chronic ingestion of a Western diet increases O-linked-β-N-acetylglucosamine (O-GlcNAc) protein modification in the rat heart. Life Sciences, 90 23-24: 883-888. doi:10.1016/j.lfs.2012.04.030

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Author Medford, H. M.
Chatham, J. C.
Marsh, S. A.
Title Chronic ingestion of a Western diet increases O-linked-β-N-acetylglucosamine (O-GlcNAc) protein modification in the rat heart
Journal name Life Sciences   Check publisher's open access policy
ISSN 0024-3205
1879-0631
Publication date 2012-06-14
Sub-type Article (original research)
DOI 10.1016/j.lfs.2012.04.030
Open Access Status Not yet assessed
Volume 90
Issue 23-24
Start page 883
End page 888
Total pages 6
Place of publication Philadelphia, PA United States
Publisher Elsevier
Language eng
Formatted abstract
Protein O-GlcNAcylation is both a nutrient sensing and cellular stress response that mediates signal transduction in the heart. Chronically elevated O-GlcNAc has been associated with the development of cardiac dysfunction at both the cellular and organ levels in obesity, insulin resistance and diabetes. Development of these pathologies is often attributed to diets high in saturated fat and sugar (a “Western” diet; WES) but a role for O-GlcNAc in diet-induced cardiac dysfunction has not been established. The aims of this study were to examine the effect of chronic consumption of WES on cardiac O-GlcNAcylation and investigate associations of O-GlcNAc with cardiac function and markers of cellular stress.
Keyword Western diet; saturated fat
Cardiac metabolism
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Human Movement and Nutrition Sciences Publications
 
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Created: Tue, 02 Dec 2014, 20:14:01 EST by Sandrine Ducrot on behalf of School of Human Movement and Nutrition Sciences