Carotid ultrasound pulsatility indices and cardiovascular risk in Australian women

Oughton, Justin Alexander, Rose, Stephen, Galloway, Graham, Khoo, Soo Keat, O'Neill, Sheila and Coulthard, Alan (2015) Carotid ultrasound pulsatility indices and cardiovascular risk in Australian women. Journal of Medical Imaging and Radiation Oncology, 59 1: 20-25. doi:10.1111/1754-9485.12250

Author Oughton, Justin Alexander
Rose, Stephen
Galloway, Graham
Khoo, Soo Keat
O'Neill, Sheila
Coulthard, Alan
Title Carotid ultrasound pulsatility indices and cardiovascular risk in Australian women
Journal name Journal of Medical Imaging and Radiation Oncology   Check publisher's open access policy
ISSN 1754-9477
Publication date 2015-02-01
Year available 2014
Sub-type Article (original research)
DOI 10.1111/1754-9485.12250
Open Access Status Not Open Access
Volume 59
Issue 1
Start page 20
End page 25
Total pages 6
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell
Language eng
Formatted abstract
Introduction: Ultrasound-acquired internal carotid arterial (ICA) pulsatility indices (PI) have been demonstrated to be useful measures of cerebrovascular disease. The purpose of this cross-sectional study was to investigate the association between carotid artery PI, cardiovascular risk and ischaemic heart disease in aging women.

Methods: One hundred and fifty-eight female participants of the Longitudinal Assessment of Ageing in Women study, aged 48–85 years, were evaluated. The relationships between common carotid artery (CCA) and ICA Doppler PI to cardiovascular risk factors (age, body mass index, systolic and mean arterial blood pressure, smoking and diabetes), carotid–femoral (femPWV) and carotid–radial (radPWV) pulse wave velocities, and ischaemic heart disease (IHD) were assessed using Spearman's rank correlation (ρ), multiple regression and logistic regression. Dependent variables were Box–Cox transformed to meet linear regression assumptions.

Results: CCA and ICA PI were significantly correlated to femPWV (ρ = 0.414 and ρ = 0.544, respectively). Cardiovascular risk factors were significantly predictive of CCA PI (Adj R2 = 0.176, P < 0.01); however, their relationship to ICA PI (Adj R2 = 0.508, P < 0.01) was stronger. This result was comparable with the relationship between cardiovascular risk factors and femPWV (Adj R2 = 0.561, P < 0.01). Age and systolic blood pressure were the dominant risk factors for IHD in this group.

Conclusion: ICA PI is comparable with femPWV in its association with cardiovascular disease. PI does not improve the prediction of IHD over age and systolic blood pressure.
Keyword Aging
Cardiovascular risk
Carotid artery
Pulsatility index
Pulse wave velocity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
Centre for Advanced Imaging Publications
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Created: Thu, 27 Nov 2014, 20:04:39 EST by Shona Osborne on behalf of Centre for Advanced Imaging