Defining the role of common variation in the genomic and biological architecture of adult human height

Wood, Andrew R., Esko, Tonu, Yang, Jian, Vedantam, Sailaja, Pers, Tune H., Gustafsson, Stefan, Chu, Audrey Y., Estrada, Karol, Luan, Jian'an, Kutalik, Zoltan, Amin, Najaf, Buchkovich, Martin L., Croteau-Chonka, Damien C., Day, Felix R., Duan, Yanan, Fall, Tove, Fehrmann, Rudolf, Ferreira, Teresa, Jackson, Anne U., Karjalainen, Juha, Lo, Ken Sin, Locke, Adam E., Magi, Reedik, Mihailov, Evelin, Porcu, Evelin, Randall, Joshua C., Scherag, Andre, Vinkhuyzen, Anne A. E., Westra, Harm-Jan, Winkler, Thomas W., Workalemahu, Tsegaselassie, Zhao, Jing Hua, Absher, Devin, Albrecht, Eva, Anderson, Denise, Baron, Jeffrey, Beekman, Marian, Demirkan, Ayse, Ehret, Georg B., Feenstra, Bjarke, Feitosa, Mary F., Fischer, Krista, Fraser, Ross M., Goel, Anuj, Gong, Jian, Justice, Anne E., Kanoni, Stavroula, Kleber, Marcus E., Kristiansson, Kati, Lim, Unhee, Lotay, Vaneet, Lui, Julian C., Mangino, Massimo, Leach, Irene Mateo, Medina-Gomez, Carolina, Nalls, Michael A., Nyholt, Dale R., Palmer, Cameron D., Pasko, Dorota, Pechlivanis, Sonali, Prokopenko, Inga, Ried, Janina S., Ripke, Stephan, Shungin, Dmitry, Stancakova, Alena, Strawbridge, Rona J., Sung, Yun Ju, Tanaka, Toshiko, Teumer, Alexander, Trompet, Stella, van der Laan, Sander W., van Setten, Jessica, Van Vliet-Ostaptchouk, Jana V., Wang, Zhaoming, Yengo, Loic, Zhang, Weihua, Afzal, Uzma, Arnlov, Johan, Arscott, Gillian M., Bandinelli, Stefania, Barrett, Amy, Bellis, Claire, Bennett, Amanda J., Berne, Christian, Bluher, Matthias, Bolton, Jennifer L., Bottcher, Yvonne, Boyd, Heather A., Bruinenberg, Marcel, Buckley, Brendan M., Buyske, Steven, Caspersen, Ida H., Chines, Peter S., Clarke, Robert, Claudi-Boehm, Simone, Cooper, Matthew, Daw, E. Warwick, De Jong, Pim A., Deelen, Joris, Delgado, Graciela, Denny, Josh C., Dhonukshe-Rutten, Rosalie, Dimitriou, Maria, Doney, Alex S. F., Dorr, Marcus, Eklund, Niina, Eury, Elodie, Folkersen, Lasse, Garcia, Melissa E., Geller, Frank, Giedraitis, Vilmantas, Go, Alan S., Grallert, Harald, Grammer, Tanja B., Grassler, Jurgen, Gronberg, Henrik, de Groot, Lisette C. P. G. M., Groves, Christopher J., Haessler, Jeffrey, Hall, Per, Haller, Toomas, Hallmans, Goran, Hannemann, Anke, Hartman, Catharina A., Hassinen, Maija, Hayward, Caroline, Heard-Costa, Nancy L., Helmer, Quinta, Hemani, Gibran, Henders, Anjali K., Hillege, Hans L., Hlatky, Mark A., Hoffmannm Wolfgang, Hoffmann, Per, Holmen, Oddgeir, Houwing-Duistermaat, Jeanine J., Illig, Thomas, Isaacs, Aaron, James, Alan L., Jeff, Jarina, Johansen, Berit, Johansson, Asa, Jolley, Jennifer, Juliusdottir, Thorhildur, Junttila, Juhani, Kho, Abel N., Kinnunen, Leena, Klopp, Norman, Kocher, Thomas, Kratzer, Wolfgang, Lichtner, Peter, Lind, Lars, Lindstrom, Jaana, Lobbens, Stephane, Lorentzon, Matthias, Lu, Yingchang, Lyssenko, Valeriya, Magnusson, Patrik K. E., Mahajan, Anubha, Maillard, Marc, McArdle, Wendy L., McKenzie, Colin A., McLachlan, Stela, McLaren, Paul J., Menni, Cristina, Merger, Sigrun, Milani, Lili, Moayyeri, Alireza, Monda, Keri L., Morken, Mario A., Muller, Gabriele, Muller-Nurasyid, Martina, Musk, Arthur W., Narisu, Narisu, Nauck, Matthias, Nolte, Ilja M., Nothen, Markus M., Oozageer, Laticia, Pilz, Stefan, Rayner, Nigel W., Renstrom, Frida, Robertson, Neil R., Rose, Lynda M., Roussel, Ronan, Sanna, Serena, Scharnagl, Hubert, Scholtens, Salome, Schumacher, Fredrick R., Schunkert, Heribert, Scott, Robert A., Sehmi, Joban, Seufferlein, Thomas, Shi, Jianxin, Silventoinen, Karri, Smit, Johannes H., Smith, Albert Vernon, Smolonska, Joanna, Stanton, Alice V., Stirrups, Kathleen, Stott, David J., Stringham, Heather M., Sundstrom, Johan, Swertz, Morris A., Syvanen, Ann-Christine, Tayo, Bamidele O., Thorleifsson, Gudmar, Tyrer, Jonathan P., van Dijk, Suzanne, van Schoor, Natasja M., van der Velde, Nathalie, van Heemst, Diana, van Oort, Floor V. A., Vermeulen, Sita H., Verweij, Niek, Vonk, Judith M., Waite, Lindsay L., Waldenberger, Melanie, Wennauer, Roman, Wilkens, Lynne R., Willenborg, Christina, Wilsgaard, Tom, Wojczynski, Mary K., Wong, Andrew, Wright, Alan F., Zhang, Qunyuan, Arveiler, Dominique, Bakker, Stephan J. L., Beilby, John, Bergman, Richard N., Bergmann, Sven, Biffar, Reiner, Blangero, John, Boomsma, Dorret I., Bornstein, Stefan R., Bovet, Pascal, Brambilla, Paolo, Brown, Morris J., Campbell, Harry, Caulfield, Mark J., Chakravarti, Aravinda, Collins, Rory, Collins, Francis S., Crawford, Dana C., Cupples, L. Adrienne, Danesh, John, de Faire, Ulf, den Ruijter Hester M., Erbel, Raimund, Erdmann, Jeanette, Eriksson, Johan G., Farrall, Martin, Ferrannini, Ele, Ferrieres, Jean, Ford, Ian, Forouhi, Nita G., Forrester, Terrence, Gansevoort, Ron T., Gejman, Pablo V., Gieger, Christian, Golay, Alain, Gottesman, Omri, Gudnason, Vilmundur, Gyllensten, Ulf, Haas, David W., Hall, Alistair S., Harris, Tamara B., Hattersley, Andrew T., Heath, Andrew C., Hengstenberg, Christian, Hicks, Andrew A., Hindorff, Lucia A., Hingorani, Aroon D., Hofman, Albert, Hovingh, G. Kees, Humphries, Steve E., Hunt, Steven C., Hypponen, Elina, Jacobs, Kevin B., Jarvelin, Marjo-Riitta, Jousilahti, Pekka, Jula, Antti M., Kaprio, Jaakko, Kastelein, John J. P., Kayser, Manfred, Kee, Frank, Keinanen-Kiukaanniemi, Sirkka M., Kiemeney, Lambertus A., Kooner, Jaspal S., Kooperberg, Charles, Koskinen, Seppo, Kovacs, Peter, Kraja, Aldi T., Kumari, Meena, Kuusisto, Johanna, Lakka, Timo A., Langenberg, Claudia, Le Marchandm Loic, Lehtimaki, Terho, Lupoli, Sara, Madden, Pamela A. F., Mannisto, Satu, Manunta, Paolo, Marette, Andre, Matise, Tara C., McKnight, Barbara, Meitinger, Thomas, Moll, Frans L., Montgomery, Grant W., Morris, Andrew D., Morris, Andrew P., Murray, Jeffrey C., Nelis, Mari, Ohlsson, Claes, Oldehinkel, Albertine J., Ong, Ken K., Ouwehand, Willem H., Pasterkamp, Gerard, Peters, Annette, Pramstaller, Peter P., Price, Jackie F., Qi, Lu, Raitakari, Olli T., Rankinen, Tuomo, Rao, D. C., Rice, Treva K., Ritchie, Marylyn, Rudan, Igor, Salomaa, Veikko, Samani, Nilesh J., Saramies, Jouko, Sarzynski, Mark A., Schwarz, Peter E. H., Sebert, Sylvain, Sever, Peter, Shuldiner, Alan R., Sinisalo, Juha, Steinthorsdottir, Valgerdur, Stolk, Ronald P., Tardif, Jean-Claude, Tonjes, Anke, Tremblay, Angelo, Tremoli, Elena, Virtamo, Jarmo, Vohl, Marie-Claude, Amouyel, Philippe, Asselbergs, Folkert W., Assimes, Themistocles L., Bochud, Murille, Boehm, Bernhard O., Boerwinkle, Eric, Bottinger, Erwin P., Bouchard, Claude, Cauchi, Stephane, Chambers, John C., Chanock, Stephen J., Cooper, Richard S., de Bakker Paul I. W., Dedoussis, George, Ferrucci, Luigi, Franks, Paul W., Froguel, Philippe, Groop, Leif C., Haiman, Christopher A., Hamsten, Anders, Hayes, M. Geoffrey, Hui, Jennie, Hunter, David J., Hveem, Kristian, Jukema, J. Wouter, Kaplan, Robert C., Kivimaki, Mika, Kuh, Diana, Laakso, Markku, Liu, Yongmei, Martin, Nicholas G., Marz, Winfried, Melbye, Mads, Moebus, Susanne, Munroe, Patricia B., Njolstad, Inger, Oostra, Ben A., Palmer, Colin N. A., Pedersen, Nancy L., Perola, Markus, Perusse, Louis, Peters, Ulrike, Powell, Joseph E., Power, Chris, Quertermous, Thomas, Rauramaa, Rainer, Reinmaa, Eva, Ridker, Paul M., Rivadeneira, Fernando, Rotter, Jerome I., Saaristo, Timo E., Saleheen, Danish, Schlessinger, David, Slagboom, P. Eline, Snieder, Harold, Spector, Tim D., Strauch, Konstantin, Stumvoll, Michael, Tuomilehto, Jaakko, Uusitupa, Matti, van der Harst, Pim, Volzke, Henry, Walker, Mark, Wareham, Nicholas J., Watkins, Hugh, Wichmann, H.-Erich, Wilson, James F., Zanen, Pieter, Deloukas, Panos, Heid, Iris M., Lindgren, Cecilia M., Mohlke, Karen L., Speliotes, Elizabeth K., Thorsteinsdottir, Unnur, Barroso, Ines, Fox, Caroline S., North, Kari E., Strachan, David P., Beckmann, Jacques S., Berndt, Sonja I., Boehnke, Michael, Borecki, Ingrid B., McCarthy, Mark I., Metspalu, Andres, Stefansson, Kari, Uitterlinden, Andre G., van Duijn Cornelia M., Franke, Lude, Willer, Cristen J., Price, Alkes L., Lettre, Guillaume, Loos, Ruth J. F., Weedon, Michael N., Ingelsson, Erik, O'Connell, Jeffrey R., Abecasis, Goncalo R., Chasman, Daniel I., Goddard, Michael E., Visscher, Peter M., Hirschhorn, Joel N. and Frayling, Timothy M. (2014) Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics, 46 11: 1173-1186. doi:10.1038/ng.3097


Author Wood, Andrew R.
Esko, Tonu
Yang, Jian
Vedantam, Sailaja
Pers, Tune H.
Gustafsson, Stefan
Chu, Audrey Y.
Estrada, Karol
Luan, Jian'an
Kutalik, Zoltan
Amin, Najaf
Buchkovich, Martin L.
Croteau-Chonka, Damien C.
Day, Felix R.
Duan, Yanan
Fall, Tove
Fehrmann, Rudolf
Ferreira, Teresa
Jackson, Anne U.
Karjalainen, Juha
Lo, Ken Sin
Locke, Adam E.
Magi, Reedik
Mihailov, Evelin
Porcu, Evelin
Randall, Joshua C.
Scherag, Andre
Vinkhuyzen, Anne A. E.
Westra, Harm-Jan
Winkler, Thomas W.
Workalemahu, Tsegaselassie
Zhao, Jing Hua
Absher, Devin
Albrecht, Eva
Anderson, Denise
Baron, Jeffrey
Beekman, Marian
Demirkan, Ayse
Ehret, Georg B.
Feenstra, Bjarke
Feitosa, Mary F.
Fischer, Krista
Fraser, Ross M.
Goel, Anuj
Gong, Jian
Justice, Anne E.
Kanoni, Stavroula
Kleber, Marcus E.
Kristiansson, Kati
Lim, Unhee
Lotay, Vaneet
Lui, Julian C.
Mangino, Massimo
Leach, Irene Mateo
Medina-Gomez, Carolina
Nalls, Michael A.
Nyholt, Dale R.
Palmer, Cameron D.
Pasko, Dorota
Pechlivanis, Sonali
Prokopenko, Inga
Ried, Janina S.
Ripke, Stephan
Shungin, Dmitry
Stancakova, Alena
Strawbridge, Rona J.
Sung, Yun Ju
Tanaka, Toshiko
Teumer, Alexander
Trompet, Stella
van der Laan, Sander W.
van Setten, Jessica
Van Vliet-Ostaptchouk, Jana V.
Wang, Zhaoming
Yengo, Loic
Zhang, Weihua
Afzal, Uzma
Arnlov, Johan
Arscott, Gillian M.
Bandinelli, Stefania
Barrett, Amy
Bellis, Claire
Bennett, Amanda J.
Berne, Christian
Bluher, Matthias
Bolton, Jennifer L.
Bottcher, Yvonne
Boyd, Heather A.
Bruinenberg, Marcel
Buckley, Brendan M.
Buyske, Steven
Caspersen, Ida H.
Chines, Peter S.
Clarke, Robert
Claudi-Boehm, Simone
Cooper, Matthew
Daw, E. Warwick
De Jong, Pim A.
Deelen, Joris
Delgado, Graciela
Denny, Josh C.
Dhonukshe-Rutten, Rosalie
Dimitriou, Maria
Doney, Alex S. F.
Dorr, Marcus
Eklund, Niina
Eury, Elodie
Folkersen, Lasse
Garcia, Melissa E.
Geller, Frank
Giedraitis, Vilmantas
Go, Alan S.
Grallert, Harald
Grammer, Tanja B.
Grassler, Jurgen
Gronberg, Henrik
de Groot, Lisette C. P. G. M.
Groves, Christopher J.
Haessler, Jeffrey
Hall, Per
Haller, Toomas
Hallmans, Goran
Hannemann, Anke
Hartman, Catharina A.
Hassinen, Maija
Hayward, Caroline
Heard-Costa, Nancy L.
Helmer, Quinta
Hemani, Gibran
Henders, Anjali K.
Hillege, Hans L.
Hlatky, Mark A.
Hoffmannm Wolfgang
Hoffmann, Per
Holmen, Oddgeir
Houwing-Duistermaat, Jeanine J.
Illig, Thomas
Isaacs, Aaron
James, Alan L.
Jeff, Jarina
Johansen, Berit
Johansson, Asa
Jolley, Jennifer
Juliusdottir, Thorhildur
Junttila, Juhani
Kho, Abel N.
Kinnunen, Leena
Klopp, Norman
Kocher, Thomas
Kratzer, Wolfgang
Lichtner, Peter
Lind, Lars
Lindstrom, Jaana
Lobbens, Stephane
Lorentzon, Matthias
Lu, Yingchang
Lyssenko, Valeriya
Magnusson, Patrik K. E.
Mahajan, Anubha
Maillard, Marc
McArdle, Wendy L.
McKenzie, Colin A.
McLachlan, Stela
McLaren, Paul J.
Menni, Cristina
Merger, Sigrun
Milani, Lili
Moayyeri, Alireza
Monda, Keri L.
Morken, Mario A.
Muller, Gabriele
Muller-Nurasyid, Martina
Musk, Arthur W.
Narisu, Narisu
Nauck, Matthias
Nolte, Ilja M.
Nothen, Markus M.
Oozageer, Laticia
Pilz, Stefan
Rayner, Nigel W.
Renstrom, Frida
Robertson, Neil R.
Rose, Lynda M.
Roussel, Ronan
Sanna, Serena
Scharnagl, Hubert
Scholtens, Salome
Schumacher, Fredrick R.
Schunkert, Heribert
Scott, Robert A.
Sehmi, Joban
Seufferlein, Thomas
Shi, Jianxin
Silventoinen, Karri
Smit, Johannes H.
Smith, Albert Vernon
Smolonska, Joanna
Stanton, Alice V.
Stirrups, Kathleen
Stott, David J.
Stringham, Heather M.
Sundstrom, Johan
Swertz, Morris A.
Syvanen, Ann-Christine
Tayo, Bamidele O.
Thorleifsson, Gudmar
Tyrer, Jonathan P.
van Dijk, Suzanne
van Schoor, Natasja M.
van der Velde, Nathalie
van Heemst, Diana
van Oort, Floor V. A.
Vermeulen, Sita H.
Verweij, Niek
Vonk, Judith M.
Waite, Lindsay L.
Waldenberger, Melanie
Wennauer, Roman
Wilkens, Lynne R.
Willenborg, Christina
Wilsgaard, Tom
Wojczynski, Mary K.
Wong, Andrew
Wright, Alan F.
Zhang, Qunyuan
Arveiler, Dominique
Bakker, Stephan J. L.
Beilby, John
Bergman, Richard N.
Bergmann, Sven
Biffar, Reiner
Blangero, John
Boomsma, Dorret I.
Bornstein, Stefan R.
Bovet, Pascal
Brambilla, Paolo
Brown, Morris J.
Campbell, Harry
Caulfield, Mark J.
Chakravarti, Aravinda
Collins, Rory
Collins, Francis S.
Crawford, Dana C.
Cupples, L. Adrienne
Danesh, John
de Faire, Ulf
den Ruijter Hester M.
Erbel, Raimund
Erdmann, Jeanette
Eriksson, Johan G.
Farrall, Martin
Ferrannini, Ele
Ferrieres, Jean
Ford, Ian
Forouhi, Nita G.
Forrester, Terrence
Gansevoort, Ron T.
Gejman, Pablo V.
Gieger, Christian
Golay, Alain
Gottesman, Omri
Gudnason, Vilmundur
Gyllensten, Ulf
Haas, David W.
Hall, Alistair S.
Harris, Tamara B.
Hattersley, Andrew T.
Heath, Andrew C.
Hengstenberg, Christian
Hicks, Andrew A.
Hindorff, Lucia A.
Hingorani, Aroon D.
Hofman, Albert
Hovingh, G. Kees
Humphries, Steve E.
Hunt, Steven C.
Hypponen, Elina
Jacobs, Kevin B.
Jarvelin, Marjo-Riitta
Jousilahti, Pekka
Jula, Antti M.
Kaprio, Jaakko
Kastelein, John J. P.
Kayser, Manfred
Kee, Frank
Keinanen-Kiukaanniemi, Sirkka M.
Kiemeney, Lambertus A.
Kooner, Jaspal S.
Kooperberg, Charles
Koskinen, Seppo
Kovacs, Peter
Kraja, Aldi T.
Kumari, Meena
Kuusisto, Johanna
Lakka, Timo A.
Langenberg, Claudia
Le Marchandm Loic
Lehtimaki, Terho
Lupoli, Sara
Madden, Pamela A. F.
Mannisto, Satu
Manunta, Paolo
Marette, Andre
Matise, Tara C.
McKnight, Barbara
Meitinger, Thomas
Moll, Frans L.
Montgomery, Grant W.
Morris, Andrew D.
Morris, Andrew P.
Murray, Jeffrey C.
Nelis, Mari
Ohlsson, Claes
Oldehinkel, Albertine J.
Ong, Ken K.
Ouwehand, Willem H.
Pasterkamp, Gerard
Peters, Annette
Pramstaller, Peter P.
Price, Jackie F.
Qi, Lu
Raitakari, Olli T.
Rankinen, Tuomo
Rao, D. C.
Rice, Treva K.
Ritchie, Marylyn
Rudan, Igor
Salomaa, Veikko
Samani, Nilesh J.
Saramies, Jouko
Sarzynski, Mark A.
Schwarz, Peter E. H.
Sebert, Sylvain
Sever, Peter
Shuldiner, Alan R.
Sinisalo, Juha
Steinthorsdottir, Valgerdur
Stolk, Ronald P.
Tardif, Jean-Claude
Tonjes, Anke
Tremblay, Angelo
Tremoli, Elena
Virtamo, Jarmo
Vohl, Marie-Claude
Amouyel, Philippe
Asselbergs, Folkert W.
Assimes, Themistocles L.
Bochud, Murille
Boehm, Bernhard O.
Boerwinkle, Eric
Bottinger, Erwin P.
Bouchard, Claude
Cauchi, Stephane
Chambers, John C.
Chanock, Stephen J.
Cooper, Richard S.
de Bakker Paul I. W.
Dedoussis, George
Ferrucci, Luigi
Franks, Paul W.
Froguel, Philippe
Groop, Leif C.
Haiman, Christopher A.
Hamsten, Anders
Hayes, M. Geoffrey
Hui, Jennie
Hunter, David J.
Hveem, Kristian
Jukema, J. Wouter
Kaplan, Robert C.
Kivimaki, Mika
Kuh, Diana
Laakso, Markku
Liu, Yongmei
Martin, Nicholas G.
Marz, Winfried
Melbye, Mads
Moebus, Susanne
Munroe, Patricia B.
Njolstad, Inger
Oostra, Ben A.
Palmer, Colin N. A.
Pedersen, Nancy L.
Perola, Markus
Perusse, Louis
Peters, Ulrike
Powell, Joseph E.
Power, Chris
Quertermous, Thomas
Rauramaa, Rainer
Reinmaa, Eva
Ridker, Paul M.
Rivadeneira, Fernando
Rotter, Jerome I.
Saaristo, Timo E.
Saleheen, Danish
Schlessinger, David
Slagboom, P. Eline
Snieder, Harold
Spector, Tim D.
Strauch, Konstantin
Stumvoll, Michael
Tuomilehto, Jaakko
Uusitupa, Matti
van der Harst, Pim
Volzke, Henry
Walker, Mark
Wareham, Nicholas J.
Watkins, Hugh
Wichmann, H.-Erich
Wilson, James F.
Zanen, Pieter
Deloukas, Panos
Heid, Iris M.
Lindgren, Cecilia M.
Mohlke, Karen L.
Speliotes, Elizabeth K.
Thorsteinsdottir, Unnur
Barroso, Ines
Fox, Caroline S.
North, Kari E.
Strachan, David P.
Beckmann, Jacques S.
Berndt, Sonja I.
Boehnke, Michael
Borecki, Ingrid B.
McCarthy, Mark I.
Metspalu, Andres
Stefansson, Kari
Uitterlinden, Andre G.
van Duijn Cornelia M.
Franke, Lude
Willer, Cristen J.
Price, Alkes L.
Lettre, Guillaume
Loos, Ruth J. F.
Weedon, Michael N.
Ingelsson, Erik
O'Connell, Jeffrey R.
Abecasis, Goncalo R.
Chasman, Daniel I.
Goddard, Michael E.
Visscher, Peter M.
Hirschhorn, Joel N.
Frayling, Timothy M.
Title Defining the role of common variation in the genomic and biological architecture of adult human height
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1546-1718
1061-4036
Publication date 2014-11-05
Year available 2014
Sub-type Article (original research)
DOI 10.1038/ng.3097
Open Access Status DOI
Volume 46
Issue 11
Start page 1173
End page 1186
Total pages 14
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Language eng
Subject 1311 Genetics
Abstract Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ~2,000, ~3,700 and ~9,500 SNPs explained ~21%, ~24% and ~29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/β-catenin and chondroitin sulfate–related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants.
Keyword Genetics & Heredity
Genetics & Heredity
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID R01 DK093757
SP/08/002/24118
CZB/4/710
CZB/4/672
RP-PG-0310-1002
G0601463
U01 HG007419
RG/08/008/25291
G0500070
R01 HL109946
FS/11/35/28871
MC_UP_A100_1003
T32 GM080178
P30 CA015704
P01 GM099568
085301
RG/08/014/24067
R01 DK072193
FS/12/33/29561
MC_UU_12019/1
R01 DK075787
UL1 TR000124
MR/L003120/1
MC_UU_12015/1
PG/07/085/23349
MC_U106179471
P30 DK063491
P30 HD018655
FS/14/12/30540
MC_UU_12015/2
FS/12/8/29377
P30 DK072488
MC_U106179472
G1002084
090532
MC_PC_U127561128
RG/09/012/28096
098395
U01 DK062370
R01 GM075091
P30 GM103341
MR/K006584/1
MR/K013351/1
MC_UU_12015/5
323195
R01 HL117626
098381
T32 HL007055
P30 CA071789
MR/L01629X/1
RG/10/12/28456
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2015 Collection
UQ Diamantina Institute Publications
 
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