Natural Products with Anti-Bredt and Bridgehead Double Bonds

Mak, Jeffrey Y. W., Pouwer, Rebecca H. and Williams, Craig M. (2014) Natural Products with Anti-Bredt and Bridgehead Double Bonds. Angewandte Chemie International Edition, 53 50: 13664-13688. doi:10.1002/anie.201400932

Author Mak, Jeffrey Y. W.
Pouwer, Rebecca H.
Williams, Craig M.
Title Natural Products with Anti-Bredt and Bridgehead Double Bonds
Journal name Angewandte Chemie International Edition   Check publisher's open access policy
ISSN 1433-7851
Publication date 2014-11-01
Year available 2014
Sub-type Article (original research)
DOI 10.1002/anie.201400932
Volume 53
Issue 50
Start page 13664
End page 13688
Total pages 25
Place of publication Weinheim, Germany
Publisher Wiley - V C H Verlag GmbH & Co. KGaA
Language eng
Formatted abstract
Well over a hundred years ago, Professor Julius Bredt embarked on a career pursuing and critiquing bridged bicyclic systems that contained ring strain induced by the presence of a bridgehead olefin. These endeavors founded what we now know as Bredt’s rule (Bredtsche Regel). Physical, theoretical, and synthetic organic chemists have intensely studied this premise, pushing the boundaries of such systems to arrive at a better understood physical phenomenon. Mother nature has also seen fit to construct molecules containing bridgehead double bonds that encompass Bredt’s rule. For the first time, this topic is reviewed in a natural product context.
Keyword Anti Bredt
Bredt’s rule
Bridgehead alkenes
Natural products
Strained double bonds
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Chemistry and Molecular Biosciences
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 23 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 22 times in Scopus Article | Citations
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Created: Fri, 21 Nov 2014, 20:20:56 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences