A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development

Sanderson-Smith, Martina, De Oliveira, David M. P., Guglielmini, Julien, McMillan, David J., Vu, Therese, Holien, Jessica K., Henningham, Anna, Steer, Andrew C., Bessen, Debra E., Dale, James B., Curtis, Nigel, Beall, Bernard W., Walker, Mark J., Parker, Michael W., Carapetis, Jonathan R., Van Melderen, Laurence, Sriprakash, Kadaba S. and Smeesters, Pierre R. (2014) A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development. The Journal of Infectious Diseases, 210 8: 1325-1338. doi:10.1093/infdis/jiu260


Author Sanderson-Smith, Martina
De Oliveira, David M. P.
Guglielmini, Julien
McMillan, David J.
Vu, Therese
Holien, Jessica K.
Henningham, Anna
Steer, Andrew C.
Bessen, Debra E.
Dale, James B.
Curtis, Nigel
Beall, Bernard W.
Walker, Mark J.
Parker, Michael W.
Carapetis, Jonathan R.
Van Melderen, Laurence
Sriprakash, Kadaba S.
Smeesters, Pierre R.
Title A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development
Journal name The Journal of Infectious Diseases   Check publisher's open access policy
ISSN 0022-1899
1537-6613
Publication date 2014-10-01
Year available 2014
Sub-type Article (original research)
DOI 10.1093/infdis/jiu260
Open Access Status Not yet assessed
Volume 210
Issue 8
Start page 1325
End page 1338
Total pages 14
Place of publication Cary, NC United States
Publisher Oxford University Press
Language eng
Subject 2723 Immunology and Allergy
2725 Infectious Diseases
Abstract Streptococcus pyogenes ranks among the main causes of mortality from bacterial infections worldwide. Currently there is no vaccine to prevent diseases such as rheumatic heart disease and invasive streptococcal infection. The streptococcal M protein that is used as the substrate for epidemiological typing is both a virulence factor and a vaccine antigen. Over 220 variants of this protein have been described, making comparisons between proteins difficult, and hindering M protein-based vaccine development. A functional classification based on 48 emm-clusters containing closely related M proteins that share binding and structural properties is proposed. The need for a paradigm shift from type-specific immunity against S. pyogenes to emm-cluster based immunity for this bacterium should be further investigated. Implementation of this emm-cluster-based system as a standard typing scheme for S. pyogenes will facilitate the design of future studies of M protein function, streptococcal virulence, epidemiological surveillance, and vaccine development.
Formatted abstract
Streptococcus pyogenes ranks among the main causes of mortality from bacterial infections worldwide. Currently there is no vaccine to prevent diseases such as rheumatic heart disease and invasive streptococcal infection. The streptococcal M protein that is used as the substrate for epidemiological typing is both a virulence factor and a vaccine antigen. Over 220 variants of this protein have been described, making comparisons between proteins difficult, and hindering M protein-based vaccine development. A functional classification based on 48 emm-clusters containing closely related M proteins that share binding and structural properties is proposed. The need for a paradigm shift from type-specific immunity against S. pyogenes to emm-cluster based immunity for this bacterium should be further investigated. Implementation of this emm-cluster-based system as a standard typing scheme for S. pyogenes will facilitate the design of future studies of M protein function, streptococcal virulence, epidemiological surveillance, and vaccine development.
Keyword Streptococcus pyogenes
Vaccine
Fibrinogen
Plasminogen
Molecular typing
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Chemistry and Molecular Biosciences
 
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Created: Fri, 21 Nov 2014, 19:23:51 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences