Molecular psychiatry of zebrafish

Stewart, A. M ., Ullmann, J. F. P., Norton, W. H. J., Parker, M. O., Brennan, C. H., Gerlai, R. and Kalueff, A. V. (2014) Molecular psychiatry of zebrafish. Molecular Psychiatry, 20 1: 1-16. doi:10.1038/mp.2014.128

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Author Stewart, A. M .
Ullmann, J. F. P.
Norton, W. H. J.
Parker, M. O.
Brennan, C. H.
Gerlai, R.
Kalueff, A. V.
Title Molecular psychiatry of zebrafish
Journal name Molecular Psychiatry   Check publisher's open access policy
ISSN 1359-4184
1476-5578
Publication date 2014-10-28
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/mp.2014.128
Open Access Status Not yet assessed
Volume 20
Issue 1
Start page 1
End page 16
Total pages 16
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Subject 1312 Molecular Biology
2738 Psychiatry and Mental health
2804 Cellular and Molecular Neuroscience
Abstract Due to their well-characterized neural development and high genetic homology to mammals, zebrafish (Danio rerio) have emerged as a powerful model organism in the field of biological psychiatry. Here, we discuss the molecular psychiatry of zebrafish, and its implications for translational neuroscience research and modeling central nervous system (CNS) disorders. In particular, we outline recent genetic and technological developments allowing for in vivo examinations, high-throughput screening and whole-brain analyses in larval and adult zebrafish. We also summarize the application of these molecular techniques to the understanding of neuropsychiatric disease, outlining the potential of zebrafish for modeling complex brain disorders, including attention-deficit/hyperactivity disorder (ADHD), aggression, post-traumatic stress and substance abuse. Critically evaluating the advantages and limitations of larval and adult fish tests, we suggest that zebrafish models become a rapidly emerging new field in modern molecular psychiatry research.
Formatted abstract
Due to their well-characterized neural development and high genetic homology to mammals, zebrafish (Danio rerio) have emerged as a powerful model organism in the field of biological psychiatry. Here, we discuss the molecular psychiatry of zebrafish, and its implications for translational neuroscience research and modeling central nervous system (CNS) disorders. In particular, we outline recent genetic and technological developments allowing for in vivo examinations, high-throughput screening and whole-brain analyses in larval and adult zebrafish. We also summarize the application of these molecular techniques to the understanding of neuropsychiatric disease, outlining the potential of zebrafish for modeling complex brain disorders, including attention-deficit/hyperactivity disorder (ADHD), aggression, post-traumatic stress and substance abuse. Critically evaluating the advantages and limitations of larval and adult fish tests, we suggest that zebrafish models become a rapidly emerging new field in modern molecular psychiatry research.
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID NIAAA AA015325-01A2
NIDA DA030900-02
NINDS NS077295-01
Institutional Status UQ
Additional Notes Advance online publication 28 October 2014

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
Centre for Advanced Imaging Publications
 
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Created: Thu, 20 Nov 2014, 19:57:04 EST by Shona Osborne on behalf of Centre for Advanced Imaging