Progress in vaccine development

Moyle, Peter Michael (2015). Progress in vaccine development. In Richard Coico (Ed.), Current Protocols in Microbiology (pp. 18.1.1-18.1.26) Hoboken, NJ, United States: John Wiley & Sons. doi:10.1002/9780471729259.mc1801s36

Author Moyle, Peter Michael
Title of chapter Progress in vaccine development
Title of book Current Protocols in Microbiology
Place of Publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Publication Year 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/9780471729259.mc1801s36
ISBN 9780471729259
ISSN 1934-8525
Editor Richard Coico
Volume number 2015
Chapter number 18
Start page 18.1.1
End page 18.1.26
Total pages 26
Total chapters 18
Language eng
Formatted Abstract/Summary
Vaccination has a proven record as one of the most effective medical approaches to prevent the spread of infectious diseases. Traditional vaccine approaches involve the administration of whole killed or weakened microorganisms to stimulate protective immune responses. Such approaches deliver many microbial components, some of which contribute to protective immunity, and assist in guiding the type of immune response that is elicited. Despite their impeccable record, these approaches have failed to yield vaccines for many important infectious organisms. This has prompted a move towards more defined vaccines (‘subunit vaccines’), where individual protective components are administered. This unit provides an overview of the components that are used for the development of modern vaccines including: an introduction to different vaccine types (whole organism, protein/peptide, polysaccharide, conjugate, and DNA vaccines); techniques for identifying subunit antigens; vaccine delivery systems; and immunostimulatory agents (‘adjuvants’), which are fundamental for the development of effective subunit vaccines.
Keyword Adjuvants
Antigen identification
Conjugate vaccines
DNA vaccines
Peptide vaccines
Polysaccharide vaccines
Recombinant vaccines
Subunit vaccines
Toll-like receptors
Q-Index Code BX
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Thu, 20 Nov 2014, 19:15:48 EST by Peter Moyle on behalf of School of Pharmacy