Speed index in the racing quarter horse: a genome-wide association study

Meira, Camila Tangari, Fortes, Marina R. S., Farah, Michel Marques, Porto-Neto, Laercio R., Kelly, Matthew, Moore, Stephen S., Pereira, Guilherme L., Chardulo, Luis Artur Loyola and Curi, Rogerio Abdallah (2014) Speed index in the racing quarter horse: a genome-wide association study. Journal of Equine Veterinary Science, 34 11-12: 1263-1268. doi:10.1016/j.jevs.2014.09.003

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Author Meira, Camila Tangari
Fortes, Marina R. S.
Farah, Michel Marques
Porto-Neto, Laercio R.
Kelly, Matthew
Moore, Stephen S.
Pereira, Guilherme L.
Chardulo, Luis Artur Loyola
Curi, Rogerio Abdallah
Title Speed index in the racing quarter horse: a genome-wide association study
Journal name Journal of Equine Veterinary Science   Check publisher's open access policy
ISSN 0737-0806
Publication date 2014-11-01
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.jevs.2014.09.003
Open Access Status DOI
Volume 34
Issue 11-12
Start page 1263
End page 1268
Total pages 6
Place of publication Maryland Heights, MO, United States
Publisher W.B. Saunders
Language eng
Formatted abstract
The racing line of Quarter Horses is characterized by great sprinting speed over short distances on straight tracks. To perform selection on racing horses, the speed index (SI) and conformation traits are often used. A genome-wide association study (GWAS) on 112 racing Quarter Horses was performed for the SI trait, and markers and genes associated were reported. The GWAS was carried out using the Qxpak.5 software and the genotyping data obtained from the Equine SNP50 BeadChip. A total of eight significant single-nucleotide polymorphisms (SNPs) (P < .0001; Q = 0.25) distributed on Equus caballus autosomal chromosomes 2, 4, 10, 18, and 27 were found and served as markers for genomic regions mined for candidate genes associated with SI. For candidate gene, annotation was considered 100 kb windows upstream and downstream to each important SNP. The highlighted genes were GRM8, GRIK2, NEB, ANK1, and KAT6A because their function could be related to racing performance. Future studies should consider a validation study with an independent population, and sequencing of these candidate genes should be done to identify causal alleles.
Keyword Equus caballus
Single-nucleotide polymorphism
Quantitative trait
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Alliance for Agriculture and Food Innovation
Official 2015 Collection
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Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
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