The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length

Iles, Mark M., Bishop, D. Timothy, Taylor, John C., Hayward, Nicholas K., Brossard, Myriam, Cust, Anne E., Dunning, Alison M., Lee, Jeffrey E., Moses, Eric K., Akslen, Lars A., AMFS Investigators, Andresen, Per A., Avril, Marie-Francoise, Azizi, Esther, Scarra, Giovanna Bianchi, Brown, Kevin M., Debniak, Tadeusz, Elder, David E., Friedman, Eitan, Ghiorzo, Paola, Gillanders, Elizabeth M., Goldstein, Alisa M., Gruis, Nelleke A., Hansson, Johan, Harland, Mark, Helsing, Per, Hocevar, Marko, Hoiom, Veronica, IBD investigators, Ingvar, Christian, Kanetsky, Peter A., Landi, Maria Teresa, Lang, Julie, Lathrop, G. Mark, Lubinski, Jan, Mackie, Rona M., Martin, Nicholas G., Molven, Anders, Montgomery, Grant W., Novakovic, Srdjan, Olsson, Hakan, Puig, Susana, Puig-Butille, Joan Anton, QMEGA and QTWIN Investigators, Radford-Smith, Graham L., Randerson-Moor, Juliette, SDH Study Group, van der Stoep, Nienke, van Doorn, Remco, Whiteman, David C., MacGregor, Stuart, Pooley, Karen A., Ward, Sarah V., Mann, Graham J., Amos, Christopher I., Pharoah, Paul D. P., Demenais, Florence, Law, Matthew H., Bishop, Julia A. Newton, Barrett, Jennifer H., on behalf of the GenoMEL Consortium, Smithers, Mark and Visscher, Peter (2014) The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length. JNCI Journal of the National Cancer Institute, 106 10: . doi:10.1093/jnci/dju267

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Author Iles, Mark M.
Bishop, D. Timothy
Taylor, John C.
Hayward, Nicholas K.
Brossard, Myriam
Cust, Anne E.
Dunning, Alison M.
Lee, Jeffrey E.
Moses, Eric K.
Akslen, Lars A.
AMFS Investigators
Andresen, Per A.
Avril, Marie-Francoise
Azizi, Esther
Scarra, Giovanna Bianchi
Brown, Kevin M.
Debniak, Tadeusz
Elder, David E.
Friedman, Eitan
Ghiorzo, Paola
Gillanders, Elizabeth M.
Goldstein, Alisa M.
Gruis, Nelleke A.
Hansson, Johan
Harland, Mark
Helsing, Per
Hocevar, Marko
Hoiom, Veronica
IBD investigators
Ingvar, Christian
Kanetsky, Peter A.
Landi, Maria Teresa
Lang, Julie
Lathrop, G. Mark
Lubinski, Jan
Mackie, Rona M.
Martin, Nicholas G.
Molven, Anders
Montgomery, Grant W.
Novakovic, Srdjan
Olsson, Hakan
Puig, Susana
Puig-Butille, Joan Anton
QMEGA and QTWIN Investigators
Radford-Smith, Graham L.
Randerson-Moor, Juliette
SDH Study Group
van der Stoep, Nienke
van Doorn, Remco
Whiteman, David C.
MacGregor, Stuart
Pooley, Karen A.
Ward, Sarah V.
Mann, Graham J.
Amos, Christopher I.
Pharoah, Paul D. P.
Demenais, Florence
Law, Matthew H.
Bishop, Julia A. Newton
Barrett, Jennifer H.
on behalf of the GenoMEL Consortium
Smithers, Mark
Visscher, Peter
Title The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length
Journal name JNCI Journal of the National Cancer Institute   Check publisher's open access policy
ISSN 0027-8874
Publication date 2014-10-01
Year available 2014
Sub-type Article (original research)
DOI 10.1093/jnci/dju267
Volume 106
Issue 10
Total pages 5
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Formatted abstract
Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11108 case patients and 13933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-sided). A genetic score that predicts telomere length, derived from these seven SNPs, is strongly associated (P = 8.92x10-9, two-sided) with melanoma risk. This demonstrates that the previously observed association between longer telomere length and increased melanoma risk is not attributable to confounding via shared environmental effects (such as ultraviolet exposure) or reverse causality. We provide the first proof that multiple germline genetic determinants of telomere length influence cancer risk.
Keyword Genome wide association
Cancer Risk
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2015 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 24 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 17 times in Scopus Article | Citations
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