Natural product libraries: Assembly, maintenance, and screening

Butler, Mark S., Fontaine, Frank and Cooper, Matthew A. (2014) Natural product libraries: Assembly, maintenance, and screening. Planta Medica, 80 14: 1161-1170. doi:10.1055/s-0033-1360109

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Author Butler, Mark S.
Fontaine, Frank
Cooper, Matthew A.
Title Natural product libraries: Assembly, maintenance, and screening
Journal name Planta Medica   Check publisher's open access policy
ISSN 0032-0943
1439-0221
Publication date 2014-01-01
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1055/s-0033-1360109
Open Access Status File (Author Post-print)
Volume 80
Issue 14
Start page 1161
End page 1170
Total pages 10
Place of publication Stuttgart, Germany
Publisher Georg Thieme Verlag
Language eng
Abstract This review discusses successful strategies and potential pitfalls to assembling a natural product-based library suitable for high-throughput screening. Specific extraction methods for plants, microorganisms, and marine invertebrates are detailed, along with methods for generating a fractionated sub-library. The best methods to store, maintain and prepare the library for screening are addressed, as well as recommendations on how to develop a robust high-throughput assay. Finally, the logistics of moving from an assay hit to pure bioactive compound are discussed.
Keyword Extraction
Library
Natural product
Screening
Stability
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 8 times in Scopus Article | Citations
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