An emulsification-solvent evaporation route to mesoporous bioactive glass microspheres for bisphosphonate drug delivery

Zhu, Min, Shi, Jianlin, He, Qianjun, Zhang, Lingxia, Chen, Feng and Chen, Yu (2012) An emulsification-solvent evaporation route to mesoporous bioactive glass microspheres for bisphosphonate drug delivery. Journal of Materials Science, 47 5: 2256-2263. doi:10.1007/s10853-011-6037-z


Author Zhu, Min
Shi, Jianlin
He, Qianjun
Zhang, Lingxia
Chen, Feng
Chen, Yu
Title An emulsification-solvent evaporation route to mesoporous bioactive glass microspheres for bisphosphonate drug delivery
Journal name Journal of Materials Science   Check publisher's open access policy
ISSN 0022-2461
1573-4803
Publication date 2012-03-01
Sub-type Article (original research)
DOI 10.1007/s10853-011-6037-z
Volume 47
Issue 5
Start page 2256
End page 2263
Total pages 8
Place of publication New York, United States
Publisher Springer New York
Language eng
Formatted abstract
Regular spherical mesoporous bioactive glass microspheres (MBG-MSs) with tunable SiO 2-CaO-P 2O 5 composition and adjustable mesoporous structure have been synthesized by a new approach of emulsification and solvent evaporation-induced self-assembly. Less ordered mesostructure and enhanced bioactivity resulting from the addition of CaO are investigated through scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, and X-ray diffraction characterizations. The MBG-MSs have high storage capacities and sustained release patterns of anti-osteoporosis (alendronate sodium, NaAL) drugs which are hardly absorbed via oral administration. Furthermore, to some extent the dosage and release rate could also be controlled by CaO content. Cell viability and proliferation assay with rabbit bone marrow stromal cells indicates a positive effect of the CaO/P2O5 components on improving the cell growth cumulatively in about 2 weeks.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemical Engineering Publications
 
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