Double mesoporous silica shelled spherical/ellipsoidal nanostructures: synthesis and hydrophilic/hydrophobic anticancer drug delivery

Chen, Yu, Chen, Hangrong, Ma, Ming, Chen, Feng, Guo, Limin, Zhang, Lingxia and Shi, Jianlin (2011) Double mesoporous silica shelled spherical/ellipsoidal nanostructures: synthesis and hydrophilic/hydrophobic anticancer drug delivery. Journal of Materials Chemistry, 21 14: 5290-5298. doi:10.1039/c0jm04024j


Author Chen, Yu
Chen, Hangrong
Ma, Ming
Chen, Feng
Guo, Limin
Zhang, Lingxia
Shi, Jianlin
Title Double mesoporous silica shelled spherical/ellipsoidal nanostructures: synthesis and hydrophilic/hydrophobic anticancer drug delivery
Journal name Journal of Materials Chemistry   Check publisher's open access policy
ISSN 0959-9428
1364-5501
Publication date 2011-04-14
Sub-type Article (original research)
DOI 10.1039/c0jm04024j
Open Access Status Not Open Access
Volume 21
Issue 14
Start page 5290
End page 5298
Total pages 9
Place of publication Cambridge, United Kingdom
Publisher Royal Society of Chemistry
Language eng
Formatted abstract
A general electrostatic interaction-based self-assembly strategy has been developed to synthesize various composite nanostructures with double mesoporous silica shells. The outer (second) mesoporous silica shell was coated on the surface of an inner (first) mesoporous silica nanostructure (nanosphere or nanolayer), which was templated by silane coupling agent (C18TMS), according to an electrostatic interaction mechanism between the negatively charged surface of inner mesoporous silica shell/sphere and positively charged cationic surfactant (C16TAB) for directing the second shell. The two adjacent shells directed by different pore-making agents show hierarchical pore size distributions and diverse pore structure orderings. This general strategy can be extended to synthesize a series of novel double-shelled mesoporous nanostructures with various morphologies, compositions and structures by altering the structural designing scheme in nanoscale (seven novel nanostructures created in this work). Importantly, the deposition of the second mesoporous shell on the surface of initial mesoporous nanostructures significantly increases the surface areas and pore volumes of as-prepared materials, which provides an alternative and versatile post-treatment approach to tune the key structural parameters of mesoporous nanomaterials. The double shelled hollow mesoporous silica spheres were found to be highly biocompatible, and were explored as both hydrophilic and hydrophobic anticancer drug delivery vehicles against cancer cells. The results show that the deposition of a second mesoporous silica shell could lead to a sustained release of a hydrophilic anticancer drug (irinotecan) from the carriers, and moreover, the double shelled mesoporous silica spheres exhibit high hydrophobic anticancer drug (docetaxel) loading capacity (15.24%), large amount uptake by cancer cells and enhanced anticancer efficiency, indicating the potential applications of synthesized nanoparticles in nanomedicine for cancer chemotherapy.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemical Engineering Publications
 
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