Nuclear-targeted drug delivery of TAT peptide-conjugated monodisperse mesoporous silica nanoparticles

Pan, Limin, He, Qianjun, Liu, Jianan, Chen, Yu, Ma, Ming, Zhang, Linlin and Shi, Jianlin (2012) Nuclear-targeted drug delivery of TAT peptide-conjugated monodisperse mesoporous silica nanoparticles. Journal of the American Chemical Society, 134 13: 5722-5725. doi:10.1021/ja211035w


Author Pan, Limin
He, Qianjun
Liu, Jianan
Chen, Yu
Ma, Ming
Zhang, Linlin
Shi, Jianlin
Title Nuclear-targeted drug delivery of TAT peptide-conjugated monodisperse mesoporous silica nanoparticles
Journal name Journal of the American Chemical Society   Check publisher's open access policy
ISSN 0002-7863
1943-2984
Publication date 2012-04-04
Year available 2012
Sub-type Letter to editor, brief commentary or brief communication
DOI 10.1021/ja211035w
Open Access Status Not yet assessed
Volume 134
Issue 13
Start page 5722
End page 5725
Total pages 4
Place of publication Washington, DC, United States
Publisher American Chemical Society
Language eng
Abstract Most present nanodrug delivery systems have been developed to target cancer cells but rarely nuclei. However, nuclear-targeted drug delivery is expected to kill cancer cells more directly and efficiently. In this work, TAT peptide has been employed to conjugate onto mesoporous silica nanoparticles (MSNs-TAT) with high payload for nuclear-targeted drug delivery for the first time. Monodispersed MSNs-TAT of varied particle sizes have been synthesized to investigate the effects of particle size and TAT conjugation on the nuclear membrane penetrability of MSNs. MSNs-TAT with a diameter of 50 nm or smaller can efficiently target the nucleus and deliver the active anticancer drug doxorubicin (DOX) into the targeted nucleus, killing these cancer cells with much enhanced efficiencies. This study may provide an effective strategy for the design and development of cell-nuclear-targeted drug delivery.
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Letter to editor, brief commentary or brief communication
Collection: School of Mechanical & Mining Engineering Publications
 
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