Intrinsic connectivity network disruption in progressive supranuclear palsy

Gardner, Raquel C., Boxer, Adam L., Trujillo, Andrew, Mirsky, Jacob B., Guo, Christine C., Gennatas, Efstathios D., Heuer, Hilary W., Fine, Eric, Zhou, Juan, Kramer, Joel H., Miller, Bruce L. and Seeley, William W. (2013) Intrinsic connectivity network disruption in progressive supranuclear palsy. Annals of Neurology, 73 5: 603-616. doi:10.1002/ana.23844

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Author Gardner, Raquel C.
Boxer, Adam L.
Trujillo, Andrew
Mirsky, Jacob B.
Guo, Christine C.
Gennatas, Efstathios D.
Heuer, Hilary W.
Fine, Eric
Zhou, Juan
Kramer, Joel H.
Miller, Bruce L.
Seeley, William W.
Title Intrinsic connectivity network disruption in progressive supranuclear palsy
Journal name Annals of Neurology   Check publisher's open access policy
ISSN 0364-5134
Publication date 2013-05-01
Sub-type Article (original research)
DOI 10.1002/ana.23844
Open Access Status File (Author Post-print)
Volume 73
Issue 5
Start page 603
End page 616
Total pages 14
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Subject 2808 Neurology
2728 Clinical Neurology
Formatted abstract

Progressive supranuclear palsy (PSP) has been conceptualized as a large-scale network disruption, but the specific network targeted has not been fully characterized. We sought to delineate the affected network in patients with clinical PSP.

Using task-free functional magnetic resonance imaging, we mapped intrinsic connectivity to the dorsal midbrain tegmentum (dMT), a region that shows focal atrophy in PSP. Two healthy control groups (1 young, 1 older) were used to define and replicate the normal connectivity pattern, and patients with PSP were compared to an independent matched healthy control group on measures of network connectivity.

Healthy young and older subjects showed a convergent pattern of connectivity to the dMT, including brainstem, cerebellar, diencephalic, basal ganglia, and cortical regions involved in skeletomotor, oculomotor, and executive control. Patients with PSP showed significant connectivity disruptions within this network, particularly within corticosubcortical and cortico-brainstem interactions. Patients with more severe functional impairment showed lower mean dMT network connectivity scores.

This study defines a PSP-related intrinsic connectivity network in the healthy brain and demonstrates the sensitivity of network-based imaging methods to PSP-related physiological and clinical changes
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 30 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 35 times in Scopus Article | Citations
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