Anterior temporal lobe degeneration produces widespread network-driven dysfunction

Guo, Christine C., Gorno-Tempini, Maria Luisa, Gesierich Benno, Henry, Maya, Trujillo, Andrew, Shany-Ur, Tal, Jovicich, Jorge, Robinson, Simon D., Kramer, Joel H., Rankin Katherine P., Miller, Bruce L. and Seeley, William W. (2013) Anterior temporal lobe degeneration produces widespread network-driven dysfunction. Brain, 136 10: 2979-2991. doi:10.1093/brain/awt222

Author Guo, Christine C.
Gorno-Tempini, Maria Luisa
Gesierich Benno
Henry, Maya
Trujillo, Andrew
Shany-Ur, Tal
Jovicich, Jorge
Robinson, Simon D.
Kramer, Joel H.
Rankin Katherine P.
Miller, Bruce L.
Seeley, William W.
Title Anterior temporal lobe degeneration produces widespread network-driven dysfunction
Journal name Brain   Check publisher's open access policy
ISSN 0006-8950
Publication date 2013-09-01
Sub-type Article (original research)
DOI 10.1093/brain/awt222
Open Access Status DOI
Volume 136
Issue 10
Start page 2979
End page 2991
Total pages 13
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Subject 2728 Clinical Neurology
1201 Architecture
Abstract The neural organization of semantic memory remains much debated. A 'distributed-only' view contends that semantic knowledge is represented within spatially distant, modality-selective primary and association cortices. Observations in semantic variant primary progressive aphasia have inspired an alternative model featuring the anterior temporal lobe as an amodal hub that supports semantic knowledge by linking distributed modality-selective regions. Direct evidence has been lacking, however, to support intrinsic functional interactions between an anterior temporal lobe hub and upstream sensory regions in humans. Here, we examined the neural networks supporting semantic knowledge by performing a multimodal brain imaging study in healthy subjects and patients with semantic variant primary progressive aphasia. In healthy subjects, the anterior temporal lobe showed intrinsic connectivity to an array of modality-selective primary and association cortices. Patients showed focal anterior temporal lobe degeneration but also reduced physiological integrity throughout distributed modality-selective regions connected with the anterior temporal lobe in healthy controls. Physiological deficits outside the anterior temporal lobe correlated with scores on semantic tasks and with anterior temporal subregion atrophy, following domain-specific and connectivity-based predictions. The findings provide a neurophysiological basis for the theory that semantic processing is orchestrated through interactions between a critical anterior temporal lobe hub and modality-selective processing nodes.
Keyword anterior temporal lobe
functional neuroimaging
semantic dementia
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
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