Oligodendrocyte positioning in cerebral cortex is independent of projection neuron layering

Tan, Seong-Seng, Kalloniatis, Michael, Truong, Hue-Trung, Binder, Michele D., Cate, Holly S., Kilpatrick, Trevor J. and Hammond, Vicki E. (2009) Oligodendrocyte positioning in cerebral cortex is independent of projection neuron layering. Glia, 57 9: 1024-1030. doi:10.1002/glia.20826


Author Tan, Seong-Seng
Kalloniatis, Michael
Truong, Hue-Trung
Binder, Michele D.
Cate, Holly S.
Kilpatrick, Trevor J.
Hammond, Vicki E.
Title Oligodendrocyte positioning in cerebral cortex is independent of projection neuron layering
Journal name Glia   Check publisher's open access policy
ISSN 0894-1491
1098-1136
Publication date 2009-01-01
Year available 2009
Sub-type Article (original research)
DOI 10.1002/glia.20826
Open Access Status Not Open Access
Volume 57
Issue 9
Start page 1024
End page 1030
Total pages 7
Place of publication Hoboken, NJ United States
Publisher John Wiley and Sons Inc
Language eng
Subject 2804 Cellular and Molecular Neuroscience
2808 Neurology
Abstract The factors affecting normal oligodendrocyte positioning in the cerebral cortex are unknown. Apart from the white matter, the highest numbers of oligodendrocytes in the rodent cortex are found in Layers V/VI, where the infragranular neurons normally reside. Few, if any, oligodendrocytes are normally found in the superficial cortical layers. To test whether or not this asymmetric positioning of oligodendrocytes is linked to the lamina positions of Layer V/VI projection neurons, mutant mice that cause neuronal layer inversion were examined. In three lines of mutant mice (Reeler, disabled-1, and p35) examined, representing two different genetic signaling pathways, the oligodendrocyte distribution was altered from an asymmetric to a symmetric distribution pattern. Unlike cortical neurons that are inverted in these mutant mice, the lack of oligodendrocyte inversion suggests a decoupling of the genetic mechanisms governing neuronal versus oligodendrocyte patterning. We conclude that oligodendrocyte positioning is not linked to the layer positions of V/VI projection neurons.
Keyword Dab1
Neocortex
Oligodendrocytes
P35
Reelin
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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Created: Tue, 28 Oct 2014, 03:13:54 EST by Sylvie Pichelin on behalf of Queensland Brain Institute