Selectable genetic markers for nematode transgenesis

Giordano-Santini, Rosina and Dupuy, Denis (2011) Selectable genetic markers for nematode transgenesis. Cellular and Molecular Life Sciences, 68 11: 1917-1927. doi:10.1007/s00018-011-0670-1

Author Giordano-Santini, Rosina
Dupuy, Denis
Title Selectable genetic markers for nematode transgenesis
Journal name Cellular and Molecular Life Sciences   Check publisher's open access policy
ISSN 1420-682X
Publication date 2011-01-01
Sub-type Article (original research)
DOI 10.1007/s00018-011-0670-1
Open Access Status Not Open Access
Volume 68
Issue 11
Start page 1917
End page 1927
Total pages 11
Place of publication Basel, Switzerland
Publisher Birkhaeuser Science
Language eng
Abstract The nematode Caenorhabditis elegans has been used to study genetics and development since the mid-1970s. Over the years, the arsenal of techniques employed in this field has grown steadily in parallel with the number of researchers using this model. Since the introduction of C. elegans transgenesis, nearly 20 years ago, this system has been extensively used in areas such as rescue experiments, gene expression studies, and protein localization. The completion of the C. elegans genome sequence paved the way for genome-wide studies requiring higher throughput and improved scalability than provided by traditional genetic markers. The development of antibiotic selection systems for nematode transgenesis addresses these requirements and opens the possibility to apply transgenesis to investigate biological functions in other nematode species for which no genetic markers had been developed to date.
Keyword Antibiotics
Caenorhabditis elegans
Model organisms
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 27 Oct 2014, 19:21:14 EST by Debra McMurtrie on behalf of Queensland Brain Institute