Another explanation for apparent epistasis: reply

Hemani, Gibran, Shakhbazov, Konstantin, Westra, Harm-Jan, Esko, Tonu, Henders, Anjali K., McRae, Allan F., Yang, Jian, Gibson, Greg, Martin, Nicholas G., Metspalu, Andres, Franke, Lude, Montgomery, Grant W., Visscher, Peter M. and Powell, Joseph E. (2014) Another explanation for apparent epistasis: reply. Nature, 514 7520: E5-E6. doi:10.1038/nature13692


Author Hemani, Gibran
Shakhbazov, Konstantin
Westra, Harm-Jan
Esko, Tonu
Henders, Anjali K.
McRae, Allan F.
Yang, Jian
Gibson, Greg
Martin, Nicholas G.
Metspalu, Andres
Franke, Lude
Montgomery, Grant W.
Visscher, Peter M.
Powell, Joseph E.
Title Another explanation for apparent epistasis: reply
Journal name Nature   Check publisher's open access policy
ISSN 0028-0836
1476-4687
Publication date 2014-10-02
Year available 2014
Sub-type Letter to editor, brief commentary or brief communication
DOI 10.1038/nature13692
Open Access Status Not yet assessed
Volume 514
Issue 7520
Start page E5
End page E6
Total pages 2
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Subject 1000 General
Abstract Replying to A. R. Wood et al. 514, http://dx.doi.org/10.1038/nature13691 (2014).We thank Wood et al. for their interesting observations and although their proposed mechanism does not explain all our reported results, we acknowledge that alternative mechanisms could be behind the observation of epistatic signals. Although we replicate our results in large, independent samples, 19/30 of our reported interactions (Table 1 in ref. 2), Wood et al. do not replicate in the InCHIANTI data set (n = 450) at a type-I error rate of 0.05/30 = 0.002, including none of our reported cis-trans interactions. Having insufficient data to replicate the discovery interactions makes it problematic to draw firm conclusions on the reported cis-trans effects.
Keyword Multidisciplinary Sciences
Science & Technology - Other Topics
Q-Index Code CX
Q-Index Status Provisional Code
Grant ID P01 GM099568
Institutional Status UQ

Document type: Journal Article
Sub-type: Letter to editor, brief commentary or brief communication
Collections: Non HERDC
Queensland Brain Institute Publications
UQ Diamantina Institute Publications
 
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