A unified nomenclature and amino acid numbering for human PTEN

Pulido, Rafael, Baker, Suzanne J., Barata, Joao T., Carracedo, Arkaitz, Cid, Victor J., Chin-Sang, Ian D., Davé, Vrushank, Den Hertog, Jeroen, Devreotes, Peter, Eickholt, Britta J., Eng, Charis, Furnari, Frank B., Georgescu, Maria-Magdalena, Gericke, Arne, Hopkins, Benjamin, Jiang, Xeujun, Lee, Seung-Rock, Lösche, Mathias, Malaney, Prerna, Matias-Guiu, Xavier, Molina, María, Pandolfi, Pier Paolo, Parsons, Ramon, Pinton, Paolo, Rivas, Carmen, Rocha, Rafael M., Rodríguez, Manuel S., Ross, Alonzo H., Serrano, Manuel, Stambolic, Vuk, Stiles, Bangyan, Suzuki, Akira, Tan, Seong-Seng, Tonks, Nicholas K., Trotman, Lloyd C., Wolff, Nicolas, Woscholski, Rudiger, Wu, Hong and Leslie, Nicholas R. (2014) A unified nomenclature and amino acid numbering for human PTEN. Science Signaling, 7 332: . doi:10.1126/scisignal.2005560


Author Pulido, Rafael
Baker, Suzanne J.
Barata, Joao T.
Carracedo, Arkaitz
Cid, Victor J.
Chin-Sang, Ian D.
Davé, Vrushank
Den Hertog, Jeroen
Devreotes, Peter
Eickholt, Britta J.
Eng, Charis
Furnari, Frank B.
Georgescu, Maria-Magdalena
Gericke, Arne
Hopkins, Benjamin
Jiang, Xeujun
Lee, Seung-Rock
Lösche, Mathias
Malaney, Prerna
Matias-Guiu, Xavier
Molina, María
Pandolfi, Pier Paolo
Parsons, Ramon
Pinton, Paolo
Rivas, Carmen
Rocha, Rafael M.
Rodríguez, Manuel S.
Ross, Alonzo H.
Serrano, Manuel
Stambolic, Vuk
Stiles, Bangyan
Suzuki, Akira
Tan, Seong-Seng
Tonks, Nicholas K.
Trotman, Lloyd C.
Wolff, Nicolas
Woscholski, Rudiger
Wu, Hong
Leslie, Nicholas R.
Title A unified nomenclature and amino acid numbering for human PTEN
Journal name Science Signaling   Check publisher's open access policy
ISSN 1937-9145
1945-0877
Publication date 2014-07-01
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1126/scisignal.2005560
Open Access Status Not yet assessed
Volume 7
Issue 332
Total pages 4
Place of publication Washington, DC, United States
Publisher American Association for the Advancement of Science
Language eng
Formatted abstract
The tumor suppressor PTEN is a major brake for cell transformation, mainly due to its phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3] phosphatase activity that directly counteracts the oncogenicity of phosphoinositide 3-kinase (PI3K). PTEN mutations are frequent in tumors and in the germ line of patients with tumor predisposition or with neurological or cognitive disorders, which makes the PTEN gene and protein a major focus of interest in current biomedical research. After almost two decades of intense investigation on the 403-residue-long PTEN protein, a previously uncharacterized form of PTEN has been discovered that contains 173 amino-terminal extra amino acids, as a result of an alternate translation initiation site. To facilitate research in the field and to avoid ambiguities in the naming and identification of PTEN amino acids from publications and databases, we propose here a unifying nomenclature and amino acid numbering for this longer form of PTEN.
Keyword Human PTEN
Cell Transformation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
Queensland Brain Institute Publications
 
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Created: Sat, 25 Oct 2014, 01:45:58 EST by Sylvie Pichelin on behalf of Queensland Brain Institute