Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

International Schizophrenia Consortium and Wray, Naomi (2009) Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature, 460 7256: 748-752. doi:10.1038/nature08185


Author International Schizophrenia Consortium
Wray, Naomi
Title Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
Journal name Nature   Check publisher's open access policy
ISSN 0028-0836
1476-4687
Publication date 2009-01-01
Year available 2009
Sub-type Article (original research)
DOI 10.1038/nature08185
Open Access Status Not yet assessed
Volume 460
Issue 7256
Start page 748
End page 752
Total pages 5
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Subject 1000 General
Abstract Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80%(1,2). We performed a genome-wide association study of 3,322 European individuals with schizophrenia and 3,587 controls. Here we show, using two analytic approaches, the extent to which common genetic variation underlies the risk of schizophrenia. First, we implicate the major histocompatibility complex. Second, we provide molecular genetic evidence for a substantial polygenic component to the risk of schizophrenia involving thousands of common alleles of very small effect. We show that this component also contributes to the risk of bipolar disorder, but not to several non-psychiatric diseases.
Formatted abstract
HERDC Total Authors=0/Total
Keyword Multidisciplinary Sciences
Science & Technology - Other Topics
MULTIDISCIPLINARY SCIENCES
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID MH071681
CONTE: 2 P50 MH066392-05A1
FO 184/2000
MH071681
389892
Institutional Status Non-UQ
Additional Notes For ERA

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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Created: Fri, 24 Oct 2014, 03:17:21 EST by Debra McMurtrie on behalf of Queensland Brain Institute