The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data

Middeldorp, C. M., de Moor, M. H. M., McGrath, L. M., Gordon, S. D., Blackwood, D. H., Costa, P. T., Terracciano, A., Krueger, R. F., de Geus, E. J. C., Nyholt, D. R., Tanaka, T., Esko, T., Madden, P. A. F., Derringer, J., Amin, N., Willemsen, G., Hottenga, J-J., Distel, M. A., Uda, M., Sanna, S., Spinhoven, P., Hartman, C. A, Ripke, S., Sullivan, P. F., Realo, A., Allik, J., Heath, A. C., Pergadia, M. L., Agrawal, A., Lin, P., Grucza, R. A., Widen, E., Cousminer, D. L., Eriksson, J. G., Palotie, A., Barnett, J. H., Lee, P. H., Luciano, M., Tenesa, A., Davis, G., Lopez, L. M., Hansell, N. K., Medland, S. E., Ferrucci, L., Schlessinger, D., Montgomery, Grant G., Wright, M. J., Aulchenko, Y. S., Janssens, A. C. J. W., Oostra, B. A., Metspalu, A., Abecasis, G. R., Deary, I. J., Raikkonen, K., Bierut, L. J., Martin, N. G., Wray, N. R., van Duijn, C. M., Smoller, J. W., Penninx, B. W. J. H. and Boomsma, D. I. (2011) The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data. Translational Psychiatry, 1 e50.1-e50.8. doi:10.1038/tp.2011.45

Author Middeldorp, C. M.
de Moor, M. H. M.
McGrath, L. M.
Gordon, S. D.
Blackwood, D. H.
Costa, P. T.
Terracciano, A.
Krueger, R. F.
de Geus, E. J. C.
Nyholt, D. R.
Tanaka, T.
Esko, T.
Madden, P. A. F.
Derringer, J.
Amin, N.
Willemsen, G.
Hottenga, J-J.
Distel, M. A.
Uda, M.
Sanna, S.
Spinhoven, P.
Hartman, C. A
Ripke, S.
Sullivan, P. F.
Realo, A.
Allik, J.
Heath, A. C.
Pergadia, M. L.
Agrawal, A.
Lin, P.
Grucza, R. A.
Widen, E.
Cousminer, D. L.
Eriksson, J. G.
Palotie, A.
Barnett, J. H.
Lee, P. H.
Luciano, M.
Tenesa, A.
Davis, G.
Lopez, L. M.
Hansell, N. K.
Medland, S. E.
Ferrucci, L.
Schlessinger, D.
Montgomery, Grant G.
Wright, M. J.
Aulchenko, Y. S.
Janssens, A. C. J. W.
Oostra, B. A.
Metspalu, A.
Abecasis, G. R.
Deary, I. J.
Raikkonen, K.
Bierut, L. J.
Martin, N. G.
Wray, N. R.
van Duijn, C. M.
Smoller, J. W.
Penninx, B. W. J. H.
Boomsma, D. I.
Title The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data
Journal name Translational Psychiatry   Check publisher's open access policy
ISSN 2158-3188
Publication date 2011-01-01
Year available 2011
Sub-type Article (original research)
DOI 10.1038/tp.2011.45
Open Access Status DOI
Volume 1
Start page e50.1
End page e50.8
Total pages 8
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Subject 2738 Psychiatry and Mental health
2804 Cellular and Molecular Neuroscience
2803 Biological Psychiatry
Abstract The relationship between major depressive disorder (MDD) and bipolar disorder (BD) remains controversial. Previous research has reported differences and similarities in risk factors for MDD and BD, such as predisposing personality traits. For example, high neuroticism is related to both disorders, whereas openness to experience is specific for BD. This study examined the genetic association between personality and MDD and BD by applying polygenic scores for neuroticism, extraversion, openness to experience, agreeableness and conscientiousness to both disorders. Polygenic scores reflect the weighted sum of multiple single-nucleotide polymorphism alleles associated with the trait for an individual and were based on a meta-analysis of genome-wide association studies for personality traits including 13 835 subjects. Polygenic scores were tested for MDD in the combined Genetic Association Information Network (GAIN-MDD) and MDD2000 samples (N=8921) and for BD in the combined Systematic Treatment Enhancement Program for Bipolar Disorder and Wellcome Trust Case-Control Consortium samples (N=6329) using logistic regression analyses. At the phenotypic level, personality dimensions were associated with MDD and BD. Polygenic neuroticism scores were significantly positively associated with MDD, whereas polygenic extraversion scores were significantly positively associated with BD. The explained variance of MDD and BD, ∼0.1%, was highly comparable to the variance explained by the polygenic personality scores in the corresponding personality traits themselves (between 0.1 and 0.4%). This indicates that the proportions of variance explained in mood disorders are at the upper limit of what could have been expected. This study suggests shared genetic risk factors for neuroticism and MDD on the one hand and for extraversion and BD on the other.
Keyword Bipolar Disorder
Genetic correlation
Genome-wide association
Personality-major depression
Polygenic score analysis
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 076113
RO1 MH059160
U01 HG004422
201413 ENGAGE
212111 BBMRI
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 31 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 24 Oct 2014, 02:46:26 EST by Debra McMurtrie on behalf of Queensland Brain Institute