Genetic risk profiles for depression and anxiety in adult and elderly cohorts

Demirkan, A., Phenninx, B. W. J. H., Hek, K., Wray, N. R., Amin, N., Aulchenko, Y. S., van Dyck, R., de Geus, E. J. C., Hofman, A., Uitterlanden, A. G., Hottenga, J.-J., Nolen, W. A., Oostra, B. A., Sullivan, P. F., Willemsen, G., Zitman, F. G., Tiemeier, H., Janssens, A. C. J. W., Boomsma, D. I., van Duijn, C. M. and Middeldorp, C. M. (2011) Genetic risk profiles for depression and anxiety in adult and elderly cohorts. Molecular Psychiatry, 16 7: 773-783. doi:10.1038/mp.2010.65

Author Demirkan, A.
Phenninx, B. W. J. H.
Hek, K.
Wray, N. R.
Amin, N.
Aulchenko, Y. S.
van Dyck, R.
de Geus, E. J. C.
Hofman, A.
Uitterlanden, A. G.
Hottenga, J.-J.
Nolen, W. A.
Oostra, B. A.
Sullivan, P. F.
Willemsen, G.
Zitman, F. G.
Tiemeier, H.
Janssens, A. C. J. W.
Boomsma, D. I.
van Duijn, C. M.
Middeldorp, C. M.
Title Genetic risk profiles for depression and anxiety in adult and elderly cohorts
Journal name Molecular Psychiatry   Check publisher's open access policy
ISSN 1359-4184
Publication date 2011-01-01
Year available 2011
Sub-type Article (original research)
DOI 10.1038/mp.2010.65
Open Access Status Not yet assessed
Volume 16
Issue 7
Start page 773
End page 783
Total pages 11
Place of publication London, United Kingdom
Publisher Nature Publishing
Language eng
Abstract The first generation of genome-wide association studies (GWA studies) for psychiatric disorders has led to new insights regarding the genetic architecture of these disorders. We now start to realize that a larger number of genes, each with a small contribution, are likely to explain the heritability of psychiatric diseases. The contribution of a large number of genes to complex traits can be analyzed with genome-wide profiling. In a discovery sample, a genetic risk profile for depression was defined based on a GWA study of 1738 adult cases and 1802 controls. The genetic risk scores were tested in two population-based samples of elderly participants. The genetic risk profiles were evaluated for depression and anxiety in the Rotterdam Study cohort and the Erasmus Rucphen Family (ERF) study. The genetic risk scores were significantly associated with different measures of depression and explained up to 0.7% of the variance in depression in Rotterdam Study and up to 1% in ERF study. The genetic score for depression was also significantly associated with anxiety explaining up to 2.1% in Rotterdam study. These findings suggest the presence of many genetic loci of small effect that influence both depression and anxiety. Remarkably, the predictive value of these profiles was as large in the sample of elderly participants as in the middle-aged samples.
Keyword Anxiety
Genome-wide association
Risk score
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 904-61-090
SPI 56-464-14192
R01 MH059160
R01 MH074027
R01 MH077139
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
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Created: Fri, 24 Oct 2014, 02:12:56 EST by Debra McMurtrie on behalf of Queensland Brain Institute