Associations of overall sitting time and TV viewing time with fibrinogen and C reactive protein: The AusDiab study

Howard, Bethany J., Balkau, Beverley, Thorp, Alicia A., Magliano, Dianna J., Shaw, Jonathan E, Owen, Neville and Dunstan, David W. (2014) Associations of overall sitting time and TV viewing time with fibrinogen and C reactive protein: The AusDiab study. British Journal of Sports Medicine, 49 4: 255-258. doi:10.1136/bjsports-2013-093014


Author Howard, Bethany J.
Balkau, Beverley
Thorp, Alicia A.
Magliano, Dianna J.
Shaw, Jonathan E
Owen, Neville
Dunstan, David W.
Title Associations of overall sitting time and TV viewing time with fibrinogen and C reactive protein: The AusDiab study
Journal name British Journal of Sports Medicine   Check publisher's open access policy
ISSN 0306-3674
1473-0480
Publication date 2014-02-18
Year available 2014
Sub-type Article (original research)
DOI 10.1136/bjsports-2013-093014
Volume 49
Issue 4
Start page 255
End page 258
Total pages 4
Place of publication London, United Kingdom
Publisher B M J Group
Collection year 2015
Language eng
Abstract Background/aim: Sedentary behaviour is associated with increased risk for all-cause and cardiovascular mortality. Plasma fibrinogen and C reactive protein (CRP)-key inflammatory and/or haemostatic markers-may contribute to this association; however, few studies have examined their relationships with sedentary behaviours. We examined associations of overall sitting and TV viewing time with fibrinogen and high-sensitivity CRP (hsCRP). Methods: Plasma fibrinogen and hsCRP were measured in 3086 Australian adults (mean age: 55±12 years) who participated in the 2004-2005 AusDiab (Australian Diabetes, Obesity and Lifestyle) study. Multiple linear regression analyses examined cross-sectional associations of self-reported overall sitting and TV viewing time (h/day) with plasma fibrinogen and hsCRP, adjusting for sociodemographic, behavioural and medical treatments and conditions as potential covariates. Results: Overall sitting time and TV viewing time were positively associated with plasma fibrinogen (sitting: ß: 0.02 g/L, 95% CI (0.01 to 0.02); TV time: 0.03 g/L (0.02 to 0.05)) and hsCRP (sitting: 2.4% (1.2% to 3.6%); TV time: 4.5% (1.7% to 7.4%)). Associations were independent of leisure-time physical activity, but after adjusting for waist circumference, they remained for fibrinogen, but for hsCRP were attenuated to the null. Interactions were observed for gender×TV (p=0.011) with fibrinogen (associations in women only) and for waist circumference×TV (p=0.084) with hsCRP (associations in low-risk only). Conclusions: Overall sitting time was positively associated with plasma fibrinogen and hsCRP in men and women; associations of TV viewing time with fibrinogen were observed in women only. Abdominal adiposity-mediated associations for hsCRP but not for fibrinogen. Prospective and intervention studies are needed to establish likely causality and elucidate potential mechanisms.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Public Health Publications
 
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