Genetic predisposition to schizophrenia associated with increased use of cannabis

Power, R. A., Verweij, K. J. H., Zuhair, M., Montgomery, G. W., Henders, A. K., Heath, A. C., Madden, P. A. F., Medland, S. E., Wray, N. R. and Martin, N. G. (2014) Genetic predisposition to schizophrenia associated with increased use of cannabis. Molecular Psychiatry, 19 11: 1201-1204. doi:10.1038/mp.2014.51

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Author Power, R. A.
Verweij, K. J. H.
Zuhair, M.
Montgomery, G. W.
Henders, A. K.
Heath, A. C.
Madden, P. A. F.
Medland, S. E.
Wray, N. R.
Martin, N. G.
Title Genetic predisposition to schizophrenia associated with increased use of cannabis
Journal name Molecular Psychiatry   Check publisher's open access policy
ISSN 1359-4184
1476-5578
Publication date 2014-01-01
Year available 2014
Sub-type Article (original research)
DOI 10.1038/mp.2014.51
Open Access Status File (Author Post-print)
Volume 19
Issue 11
Start page 1201
End page 1204
Total pages 4
Place of publication London, United Kingdom
Publisher Nature Publishing Group.
Language eng
Abstract Cannabis is the most commonly used illicit drug worldwide. With debate surrounding the legalization and control of use, investigating its health risks has become a pressing area of research. One established association is that between cannabis use and schizophrenia, a debilitating psychiatric disorder affecting ~1% of the population over their lifetime. Although considerable evidence implicates cannabis use as a component cause of schizophrenia, it remains unclear whether this is entirely due to cannabis directly raising risk of psychosis, or whether the same genes that increases psychosis risk may also increase risk of cannabis use. In a sample of 2082 healthy individuals, we show an association between an individual’s burden of schizophrenia risk alleles and use of cannabis. This was significant both for comparing those who have ever versus never used cannabis (P=2.6 × 10−4), and for quantity of use within users (P=3.0 × 10−3). Although directly predicting only a small amount of the variance in cannabis use, these findings suggest that part of the association between schizophrenia and cannabis is due to a shared genetic aetiology. This form of gene–environment correlation is an important consideration when calculating the impact of environmental risk factors, including cannabis use.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2015 Collection
 
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