Social stress and the oxytocin receptor gene interact to predict antisocial behavior in an at-risk cohort

Smearman, Erica L., Winiarski, D. Anne, Brennan, Patricia A., Najman, Jake and Johnson, Katrina C. (2015) Social stress and the oxytocin receptor gene interact to predict antisocial behavior in an at-risk cohort. Development and Psychopathology, 27 1: 309-318. doi:10.1017/S0954579414000649


Author Smearman, Erica L.
Winiarski, D. Anne
Brennan, Patricia A.
Najman, Jake
Johnson, Katrina C.
Title Social stress and the oxytocin receptor gene interact to predict antisocial behavior in an at-risk cohort
Journal name Development and Psychopathology   Check publisher's open access policy
ISSN 0954-5794
1469-2198
Publication date 2015-02-01
Year available 2014
Sub-type Article (original research)
DOI 10.1017/S0954579414000649
Open Access Status Not yet assessed
Volume 27
Issue 1
Start page 309
End page 318
Total pages 10
Place of publication Cambridge, United Kingdom
Publisher Cambridge University Press
Language eng
Subject 3204 Developmental and Educational Psychology
2738 Psychiatry and Mental health
Abstract Polymorphisms in the oxytocin receptor gene are commonly associated with prosocial behaviors in the extant literature, yet their role in antisocial behaviors has rarely been explored, particularly during the transition from adolescence to early adulthood. We examined a prospective cohort (N = 404), collecting youth, mother, and clinician reports of conduct-disordered and antisocial behavior at ages 15 and 20. The oxytocin receptor gene rs53576 polymorphism was hypothesized to interact with social stress to predict antisocial outcomes. Structural equation modeling results revealed a significant main effect at age 15 (p = .025); those with the G allele exhibited higher levels of conduct problems. Structural equation modeling revealed a significant Gene × Environment interaction at age 20 (p = .029); those with the G allele who experienced high social stress exhibited higher levels of antisocial behavior. Heterozygous (AG) grouping models were compared, and parameter estimations supported G dominant groupings. These novel findings suggest that rs53576 polymorphisms may influence social salience and contribute to risk for antisocial outcomes, particularly under conditions of high social stress.
Keyword Life-Course-Persistent
Conduct Problems
Missing Heritability
Follow-Up
Depression
Children
Oxtr
Humans
Adolescence
Polymorphism
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID R01 MH52239
Institutional Status UQ
Additional Notes Published online ahead of print 08 July 2014.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
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