Cystic fibrosis-related bone disease explored using a four step algorithm

Brookes, D.S.K., Briody, J.N., Munns, C.F., Davies, P.S.W. and Hill, R.J. (2015) Cystic fibrosis-related bone disease explored using a four step algorithm. Journal of Cystic Fibrosis, 14 127-134. doi:10.1016/j.jcf.2014.07.011

Author Brookes, D.S.K.
Briody, J.N.
Munns, C.F.
Davies, P.S.W.
Hill, R.J.
Title Cystic fibrosis-related bone disease explored using a four step algorithm
Journal name Journal of Cystic Fibrosis   Check publisher's open access policy
ISSN 1569-1993
Publication date 2015-01-01
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.jcf.2014.07.011
Open Access Status Not Open Access
Volume 14
Start page 127
End page 134
Total pages 8
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Language eng
Subject 2740 Pulmonary and Respiratory Medicine
2735 Pediatrics, Perinatology, and Child Health
Abstract Background: A suboptimal bone accrual in young individuals with cystic fibrosis (CF) may be related to the development of a premature CF-related bone disease. Dual energy X-ray absorptiometry (DXA) is the mainstream measure of bone health; however, the influence of body size and lean tissue mass (LTM) on bone data is poorly interpreted. Methods: Total body dual-energy X-ray absorptiometry (DXA) measurements of bone mineral content (BMC) and LTM in 53 individuals with CF (7.00-17.99 years) were compared to 53 sex-matched controls. BMC, height, and LTM in relation to height and BMC Z-scores were calculated and used in a 4-step algorithm. Results: Pubertal females with CF had less total body BMC for age (p = 0.02); pre-pubertal males (p = 0.05) and pubertal females with CF (p = 0.03) were shorter; and pubertal females with CF showed less total body BMC for LTM (p = 0.01). Conclusions: The algorithm showed the following: (1) prior to puberty lowered total body BMC was primarily due to short stature, (2) LTM was appropriate for body size, and (3) pubertal females with CF had significantly less total body BMC for their LTM. Longer controlled trials are needed to clinically interpret CF-related bone disease using DXA derived data that considers patient size and body composition.
Keyword Algorithm
Cystic fibrosis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Queensland Children's Medical Research Institute Publications
School of Medicine Publications
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