Convergent functional architecture of the superior parietal lobule unraveled with multimodal neuroimaging approaches

Wang, Jiaojian, Yang, Yong, Fan, Lingzhong, Xu, Jinping, Li, Changhai, Liu, Yong, Fox, Peter T., Eickhoff, Simon B., Yu, Chunshui and Jiang, Tianzi (2014) Convergent functional architecture of the superior parietal lobule unraveled with multimodal neuroimaging approaches. Human Brain Mapping, 1-20. doi:10.1002/hbm.22626

Author Wang, Jiaojian
Yang, Yong
Fan, Lingzhong
Xu, Jinping
Li, Changhai
Liu, Yong
Fox, Peter T.
Eickhoff, Simon B.
Yu, Chunshui
Jiang, Tianzi
Title Convergent functional architecture of the superior parietal lobule unraveled with multimodal neuroimaging approaches
Journal name Human Brain Mapping   Check publisher's open access policy
ISSN 1065-9471
Publication date 2014-09-02
Year available 2014
Sub-type Article (original research)
DOI 10.1002/hbm.22626
Open Access Status Not Open Access
Start page 1
End page 20
Total pages 20
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Abstract The superior parietal lobule (SPL) plays a pivotal role in many cognitive, perceptive, and motor-related processes. This implies that a mosaic of distinct functional and structural subregions may exist in this area. Recent studies have demonstrated that the ongoing spontaneous fluctuations in the brain at rest are highly structured and, like coactivation patterns, reflect the integration of cortical locations into long-distance networks. This suggests that the internal differentiation of a complex brain region may be revealed by interaction patterns that are reflected in different neuroimaging modalities. On the basis of this perspective, we aimed to identify a convergent functional organization of the SPL using multimodal neuroimaging approaches. The SPL was first parcellated based on its structural connections as well as on its resting-state connectivity and coactivation patterns. Then, post hoc functional characterizations and connectivity analyses were performed for each subregion. The three types of connectivity-based parcellations consistently identified five subregions in the SPL of each hemisphere. The two anterior subregions were found to be primarily involved in action processes and in visually guided visuomotor functions, whereas the three posterior subregions were primarily associated with visual perception, spatial cognition, reasoning, working memory, and attention. This parcellation scheme for the SPL was further supported by revealing distinct connectivity patterns for each subregion in all the used modalities. These results thus indicate a convergent functional architecture of the SPL that can be revealed based on different types of connectivity and is reflected by different functions and interactions.
Keyword Parcellation
Structural connectivity
Functional connectivity
Behavioral domains analyses
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print 2 September 2014.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2015 Collection
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Created: Tue, 21 Oct 2014, 10:30:09 EST by System User on behalf of Queensland Brain Institute