Long-term outcomes of risk-reducing surgery in unaffected women at increased familial risk of breast and/or ovarian cancer

Heiniger, Louise, Butow, Phyllis N., Coll, Joseph, Bullen, Tracey, Wilson, Judy, Baylock, Brandi, Meiser, Bettina and Price, Melanie A. (2014) Long-term outcomes of risk-reducing surgery in unaffected women at increased familial risk of breast and/or ovarian cancer. Familial Cancer, 14 1: 105-115. doi:10.1007/s10689-014-9759-7


Author Heiniger, Louise
Butow, Phyllis N.
Coll, Joseph
Bullen, Tracey
Wilson, Judy
Baylock, Brandi
Meiser, Bettina
Price, Melanie A.
Title Long-term outcomes of risk-reducing surgery in unaffected women at increased familial risk of breast and/or ovarian cancer
Journal name Familial Cancer   Check publisher's open access policy
ISSN 1573-7292
1389-9600
Publication date 2014-10-05
Year available 2014
Sub-type Article (original research)
DOI 10.1007/s10689-014-9759-7
Open Access Status DOI
Volume 14
Issue 1
Start page 105
End page 115
Total pages 11
Place of publication Dordrecht, Netherlands
Publisher Springer Netherlands
Language eng
Subject 1311 Genetics
2730 Oncology
2716 Genetics (clinical)
1306 Cancer Research
Abstract This study prospectively investigated long-term psychosocial outcomes for women who opted for risk-reducing mastectomy (RRM) and/or risk-reducing salpingo-oophorectomy (RRSO). Unaffected women from high-risk breast cancer families who had completed baseline questionnaires for an existing study and subsequently underwent RRM and/or RRSO, completed measures of perceived breast and ovarian cancer risk, anxiety, depression, cancer-related anxiety, body image, sexual functioning, menopausal symptoms, use of hormone replacement therapy and decision regret 3 years post-surgery. Outcomes were compared to age- and risk-matched controls. Participants (N = 233) were 17 women who had RRM (39 controls), 38 women who had RRSO (94 controls) and 15 women who had RRM + RRSO (30 controls). Women who underwent RRM and those who underwent RRM + RRSO reported reductions in perceived breast cancer risk and perceived breast and ovarian cancer risk respectively, compared to their respective controls. RRM women reported greater reductions in cancer-related anxiety compared with both controls and RRSO women. RRSO women reported more sexual discomfort than controls and more urogenital menopausal symptoms than controls and RRM only women. No differences in general anxiety, depression or body image were observed. Regret was associated with greater reductions in body image since surgery and more sexual discomfort, although overall regret levels were low. Women who undergo RRM experience psychological benefits associated with reduced breast cancer risk. Although women who undergo RRSO experience some deterioration in sexual and menopausal symptoms, they do not regret their surgery decision. It is vital that women considering these procedures receive detailed information about potential psychosocial consequences.
Keyword Risk-reducing surgery
Breast
Ovarian
Psychosocial
Outcomes
Prospective
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Public Health Publications
 
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