Assessment of a decision making protocol to improve the efficacy of VELscope™ in general dental practice: A prospective evaluation

Bhatia, Nirav, Matias, Marie Anne T. and Farah, Camile S. (2014) Assessment of a decision making protocol to improve the efficacy of VELscope™ in general dental practice: A prospective evaluation. Oral Oncology, 50 10: 1012-1019. doi:10.1016/j.oraloncology.2014.07.002


Author Bhatia, Nirav
Matias, Marie Anne T.
Farah, Camile S.
Title Assessment of a decision making protocol to improve the efficacy of VELscope™ in general dental practice: A prospective evaluation
Journal name Oral Oncology   Check publisher's open access policy
ISSN 1368-8375
1879-0593
Publication date 2014-03-25
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.oraloncology.2014.07.002
Open Access Status DOI
Volume 50
Issue 10
Start page 1012
End page 1019
Total pages 8
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Language eng
Subject 3504 Oral Surgery
2730 Oncology
1306 Cancer Research
Abstract Background: VELscope™ is a device designed to help detect potentially malignant disorders of the oral mucosa at an early stage using direct tissue autofluorescence. Previous research indicates a high rate of false positives using this device. This study assesses a decision making protocol for the detection of oral mucosal lesions using conventional oral examination and VELscope™ in a general dental practice setting. Materials and methods: 305 patients presenting for general dental treatment were screened by a general dental practitioner (GDP) for oral mucosal lesions using incandescent light (conventional oral examination - COE), followed by VELscope™ and then by correlating the findings from these two examinations. A decision making protocol was followed. Patients were either reviewed or referred to an Oral Medicine specialist (OMS) for consultation, and biopsy was undertaken as required for definitive diagnosis. Results: 146 patients presented with at least one oral mucosal lesion, and a total of 222 lesions were detected. COE detected 161 oral mucosal lesions and an additional 61 lesions were detected with VELscope™. COE alone showed a sensitivity of 44.0% and specificity of 99.0% while VELscope™ alone showed a sensitivity of 64.0% and specificity of 54.3%. Using the decision making protocol, the sensitivity and specificity were 73.9% and 97.9% respectively. Conclusion: Using the decision making protocol proposed in this study allows for the detection of additional oral mucosal lesions requiring specialist referral by incorporating VELscope™ into routine general dental practice, without compromising patient care.
Keyword Early detection of cancer
Fluorescence imaging
Oral cancer
Precancerous conditions
Sensitivity and specificity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2015 Collection
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 12 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 19 Oct 2014, 10:45:37 EST by System User on behalf of UQ Centre for Clinical Research