Neonatal vitamin D status and risk of multiple sclerosis

Ueda, Peter, Rafatnia, Farshid, Baarnhielm, Maria, Frobom, Robin, Korzunowicz, Greg, Lonnerbro, Ragnar, Hedstrom, Anna Karin, Eyles, Darryl, Olsson, Tomas and Alfredsson, Lars (2014) Neonatal vitamin D status and risk of multiple sclerosis. Annals of Neurology, 76 3: 338-346. doi:10.1002/ana.24210

Author Ueda, Peter
Rafatnia, Farshid
Baarnhielm, Maria
Frobom, Robin
Korzunowicz, Greg
Lonnerbro, Ragnar
Hedstrom, Anna Karin
Eyles, Darryl
Olsson, Tomas
Alfredsson, Lars
Title Neonatal vitamin D status and risk of multiple sclerosis
Journal name Annals of Neurology   Check publisher's open access policy
ISSN 0364-5134
Publication date 2014-09-01
Year available 2014
Sub-type Article (original research)
DOI 10.1002/ana.24210
Open Access Status
Volume 76
Issue 3
Start page 338
End page 346
Total pages 9
Place of publication Hoboken NJ USA
Publisher John Wiley & Sons
Language eng
Formatted abstract
Objective: Low vitamin D status at birth may be associated with risk of adult onset multiple sclerosis, but this link has not been studied directly. We assessed the relation between neonatal vitamin D concentrations, measured in stored blood samples, and risk of multiple sclerosis.

Methods: This was a population-based case-control study in Sweden including 459 incident cases of multiple sclerosis and 663 controls, randomly drawn from a national population registry and frequency matched on sex, age, and residential area.

Results: There was no association between neonatal 25-hydroxyvitamin D quintile and risk of multiple sclerosis (crude odds ratio=1.0, 95% confidence interval=0.68-1.44, for the highest quintile compared to the lowest). Adjusting for a number of potential confounding factors in early life (month of birth, latitude of birth, breastfeeding) and in adult life (25-hydroxyvitamin D, sun exposure, vitamin D intake from dairy products, fatty fish consumption, smoking, body mass index at 20 years of age) as well as ancestry, multiple sclerosis heredity, and socioeconomic group did not considerably affect the result.

Interpretation: At a broad population level, 25-hydroxyvitamin D at birth was not associated with risk of multiple sclerosis.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2015 Collection
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Citation counts: TR Web of Science Citation Count  Cited 24 times in Thomson Reuters Web of Science Article | Citations
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