Low-dose allopurinol plus azathioprine/cyclosporin/prednisolone, a novel immunosuppressive regimen

Chocair, P, Duley, J, Simmonds, HA, Cameron, JS, Ianhez, L, Arap, S and Sabbaga, E (1993) Low-dose allopurinol plus azathioprine/cyclosporin/prednisolone, a novel immunosuppressive regimen. Lancet, 342 8863: 83-84. doi:10.1016/0140-6736(93)91287-V


Author Chocair, P
Duley, J
Simmonds, HA
Cameron, JS
Ianhez, L
Arap, S
Sabbaga, E
Title Low-dose allopurinol plus azathioprine/cyclosporin/prednisolone, a novel immunosuppressive regimen
Journal name Lancet   Check publisher's open access policy
ISSN 0140-6736
Publication date 1993-01-01
Year available 1993
Sub-type Article (original research)
DOI 10.1016/0140-6736(93)91287-V
Open Access Status Not yet assessed
Volume 342
Issue 8863
Start page 83
End page 84
Total pages 2
Place of publication LONDON
Publisher LANCET LTD
Language eng
Subject 2700 Medicine
Abstract Early rejection can still complicate renal transplantation even with cyclosporin. We added low-dose allopurinol (25 mg on alternative days) to ''triple'' immunosuppression with cyclosporin, prednisolone, and azathioprine for twelve recipients of cadaver renal grafts. The controls were fifteen patients on triple therapy alone. Only one rejection episode occurred among the allopurinol-treated patients, whereas eleven controls had rejections (seven with more than one episode). Allopurinol may be toxic when combined with azathioprine, yet the bone marrow tolerated the new regimen well. As expected, reduction of the azathioprine dose was necessary in the treated group.
Keyword Medicine, General & Internal
General & Internal Medicine
MEDICINE, GENERAL & INTERNAL
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
 
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