Uridine and its nucleotides: Biological actions, therapeutic potentials

Connolly, GP and Duley, JA (1999) Uridine and its nucleotides: Biological actions, therapeutic potentials. Trends in Pharmacological Sciences, 20 5: 218-225. doi:10.1016/S0165-6147(99)01298-5


Author Connolly, GP
Duley, JA
Title Uridine and its nucleotides: Biological actions, therapeutic potentials
Journal name Trends in Pharmacological Sciences   Check publisher's open access policy
ISSN 0165-6147
Publication date 1999-05-01
Year available 1999
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/S0165-6147(99)01298-5
Open Access Status Not yet assessed
Volume 20
Issue 5
Start page 218
End page 225
Total pages 8
Place of publication LONDON
Publisher ELSEVIER SCIENCE LONDON
Language eng
Subject 3004 Pharmacology
3005 Toxicology
Abstract There are many disorders of pyrimidine metabolism and those that involve an alteration in uridine metabolism have neurological and systemic effects, which provide insights into the biological activity of uridine and its analogues. Studies of the metabolism and actions of pyrimidines have uncovered a wealth of information on how these endogenous metabolites modulate cell physiology. In this article, the roles for the pyrimidine nucleoside uridine and its nucleotide derivatives in the regulation of a number of biological systems are examined and benefits of further studies are outlined. An understanding of how uridine and its nucleotides modulate such vastly complicated biological systems should ultimately lead to the development of new ways for modulating human physiology in both normal and diseased states. Likely targets for therapy include the respiratory, circulatory, reproductive, and nervous systems, and the treatment of cancer and HIV infection.
Keyword Pharmacology & Pharmacy
Pharmacology & Pharmacy
PHARMACOLOGY & PHARMACY
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: ResearcherID Downloads - Archived
 
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