Herbal medicines for the treatment of functional and inflammatory bowel disorders

Holtmann, Gerald and Talley, Nicholas J. (2014) Herbal medicines for the treatment of functional and inflammatory bowel disorders. Clinical Gastroenterology and Hepatology, 13 3: 422-432. doi:10.1016/j.cgh.2014.03.014

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Author Holtmann, Gerald
Talley, Nicholas J.
Title Herbal medicines for the treatment of functional and inflammatory bowel disorders
Journal name Clinical Gastroenterology and Hepatology   Check publisher's open access policy
ISSN 1542-3565
Publication date 2014-03-25
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.cgh.2014.03.014
Open Access Status File (Author Post-print)
Volume 13
Issue 3
Start page 422
End page 432
Total pages 11
Place of publication Maryland Heights, MO, USA
Publisher W.B. Saunders
Language eng
Abstract In many parts of the world, there continues to be a long-standing tradition of prescribing herbal products for a range of gastrointestinal conditions. Scientific evidence supporting the use of all herbal preparations is imperfect, however, and available studies are plagued by methodological limitations. For functional gastrointestinal disorders, there is limited evidence supporting the use of some well-characterized preparations. A number of herbals have immunomodulatory activity, and in inflammatory bowel disease there are limited positive placebo-controlled trials; other studies used active controls with suboptimal doses of the comparators. Like all drugs, herbals can lead to serious adverse events (eg, hepatic failure). Quality control is a serious issue to consider when prescribing herbal medicines. Many herbal preparations are marketed without evidence for stringent adherence to good manufacturing practice guidelines. Unpredictable environmental conditions may affect the composition and the concentration of the active ingredients of plant extracts. Further, commercial herbal products usually combine a variable plethora of chemical families with possible medicinal utility. While some of these ingredients might be of benefit, the concentration and dose of these constituents needs to be closely monitored. Physicians and regulators need to remain very cautious about the use of herbal remedies. Appropriate scientific evidence for the claimed clinical benefits should become mandatory worldwide, and the standards for production and safety monitoring should comply with established standards for chemically defined products. If these principles were adopted, the full value of herbal remedies may come to light, particularly as the individually bioactive compounds present in these preparations become recognized.
Keyword Herbal medicine
Irritable bowel syndrome
Functional dyspepsia
Inflammatory bowel disease
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Health and Behavioural Sciences -- Publications
Official 2015 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 12 times in Scopus Article | Citations
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Created: Tue, 07 Oct 2014, 22:01:51 EST by Mary-Anne Marrington on behalf of Faculty Of Health Sciences