Suppression of human melanoma cell growth and metastasis by the melanoma-associated antigen CD63 (ME491)

Radford, KJ, Mallesch, J and Hersey, P (1995) Suppression of human melanoma cell growth and metastasis by the melanoma-associated antigen CD63 (ME491). International Journal of Cancer, 62 5: 631-635. doi:10.1002/ijc.2910620523


Author Radford, KJ
Mallesch, J
Hersey, P
Title Suppression of human melanoma cell growth and metastasis by the melanoma-associated antigen CD63 (ME491)
Journal name International Journal of Cancer   Check publisher's open access policy
ISSN 0020-7136
Publication date 1995-01-01
Year available 1995
Sub-type Article (original research)
DOI 10.1002/ijc.2910620523
Open Access Status
Volume 62
Issue 5
Start page 631
End page 635
Total pages 5
Place of publication NEW YORK
Publisher WILEY-LISS
Language eng
Subject 1306 Cancer Research
2730 Oncology
Abstract CD63 has been identified in human melanoma cells by a number of different monoclonal antibodies (MAbs). Studies with MAbs have shown that expression is most marked in naevi and early forms of cutaneous melanoma and reduced in vertical growth phase and metastatic lesions. To investigate further the role of CD63 in progression of melanoma, genomic CD63 was transfected into a CD63 negative human melanoma cell line using an episomal vector. The stable transfected melanoma cells had similar growth rates to control transfected melanoma cells in vitro but much lower growth rates when injected intradermally into athymic nude mice. The CDb3-transfected cells also had a reduced number of metastases in the peritoneal cavity and subcutaneous sites when injected intravenously. MAb against CD63 did not influence the growth of CDb3-transfected melanoma cells in vitro. Our results confirm previous studies using H-ros-transformed NIH3T3 fibroblasts and suggest that CD63 may have a role as a tumor suppressor gene in human melanoma that acts to limit invasion and progression of melanoma. (C) 1995 Wiley-Liss, Inc.
Keyword Oncology
Oncology
ONCOLOGY
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
 
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