Circulating tumour-associated mucin concentrations, determined by the CASA assay, in healthy women

McGuckin, MA, Ramm, LE, Joy, GJ, Devine, PL and Ward, BG (1993) Circulating tumour-associated mucin concentrations, determined by the CASA assay, in healthy women. Clinica Chimica Acta, 214 2: 139-151. doi:10.1016/0009-8981(93)90106-E


Author McGuckin, MA
Ramm, LE
Joy, GJ
Devine, PL
Ward, BG
Title Circulating tumour-associated mucin concentrations, determined by the CASA assay, in healthy women
Journal name Clinica Chimica Acta   Check publisher's open access policy
ISSN 0009-8981
Publication date 1993-01-01
Year available 1993
Sub-type Article (original research)
DOI 10.1016/0009-8981(93)90106-E
Open Access Status
Volume 214
Issue 2
Start page 139
End page 151
Total pages 13
Place of publication AMSTERDAM
Publisher ELSEVIER SCIENCE BV
Language eng
Subject 1303 Specialist Studies in Education
1308 Clinical Biochemistry
Abstract This investigation was undertaken to establish a reference range for tumour-associated MUC1 mucins in the serum of healthy women of the ages at risk for adenocarcinoma of the ovary and breast. Blood samples and clinical information were obtained from 5,000 women attending a breast screening mammography clinic. Data from women diagnosed with breast carcinoma and those subsequently diagnosed with other cancers were omitted from the reference range. Mucin concentrations were measured using the CASA assay which detects the protein core of MUC1 encoded mucins. Multiple linear regression analysis showed no effect on CASA concentrations by non-malignant changes to the breast, menopausal status, presence/absence of the reproductive tract, parity or history of hormone use. However, CASA concentrations were significantly increased in smokers (P < 0.001) and progressively increased with age (P < 0.001). These data show that these factors must be given consideration when setting upper limits of normal using MUC1 protein core binding assays.
Keyword CASA
mucin
normal range
tumour-associated antigen
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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