Ontogeny of small RNA in the regulation of mammalian brain development

Hollins, Sharon L., Goldie, Belinda J., Carroll, Adam P., Mason, Elizabeth A., Walker, Frederick R., Eyles, Darryl W. and Cairns, Murray J. (2014) Ontogeny of small RNA in the regulation of mammalian brain development. BMC Genomics, 15 777: 1-13. doi:10.1186/1471-2164-15-777

Author Hollins, Sharon L.
Goldie, Belinda J.
Carroll, Adam P.
Mason, Elizabeth A.
Walker, Frederick R.
Eyles, Darryl W.
Cairns, Murray J.
Title Ontogeny of small RNA in the regulation of mammalian brain development
Journal name BMC Genomics   Check publisher's open access policy
ISSN 1471-2164
Publication date 2014-09-09
Year available 2014
Sub-type Article (original research)
DOI 10.1186/1471-2164-15-777
Open Access Status DOI
Volume 15
Issue 777
Start page 1
End page 13
Total pages 13
Place of publication London United Kingdom
Publisher BioMed Central
Language eng
Formatted abstract

MicroRNAs (miRNAs) play a pivotal role in coordinating messenger RNA (mRNA) transcription and stability in almost all known biological processes, including the development of the central nervous system. Despite our broad understanding of their involvement, we still have a very sparse understanding of specifically how miRNA contribute to the strict regional and temporal regulation of brain development. Accordingly, in the current study we have examined the contribution of miRNA in the developing rat telencephalon and mesencephalon from just after neural tube closure till birth using a genome-wide microarray strategy.


We identified temporally distinct expression patterns in both the telencephalon and mesencephalon for both miRNAs and their target genes. We demonstrate direct miRNA targeting of several genes involved with the migration, differentiation and maturation of neurons.


Our findings suggest that miRNA have significant implications for the development of neural structure and support important mechanisms that if disrupted, may contribute to or drive neurodevelopmental disorders.
Keyword Cortex
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2015 Collection
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Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 9 times in Scopus Article | Citations
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