Caenorhabditis elegans as a model host for Staphylococcus aureus pathogenesis

Sifri, Costi D., Begun, Jakob, Ausubel, Frederick M. and Calderwood, Stephen B. (2003) Caenorhabditis elegans as a model host for Staphylococcus aureus pathogenesis. Infection and Immunity, 71 4: 2208-2217. doi:10.1128/IAI.71.4.2208-2217.2003

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Author Sifri, Costi D.
Begun, Jakob
Ausubel, Frederick M.
Calderwood, Stephen B.
Title Caenorhabditis elegans as a model host for Staphylococcus aureus pathogenesis
Journal name Infection and Immunity
ISSN 1098-5522
Publication date 2003-04-01
Year available 2003
Sub-type Article (original research)
DOI 10.1128/IAI.71.4.2208-2217.2003
Open Access Status File (Publisher version)
Volume 71
Issue 4
Start page 2208
End page 2217
Total pages 10
Place of publication Washington, DC 20036 United States
Publisher American Society for Microbiology
Language eng
Abstract Staphylococcus aureus, an important pathogen of humans and other warm-blooded animals, is also capable of killing the nematode Caenorhabditis elegans. Here, we show that C. elegans organisms that are fed S. aureus die over the course of several days in a process that is correlated with the accumulation of bacteria within the nematode digestive tract. Several S. aureus virulence determinants known or speculated to be important in mammalian pathogenesis, including the quorum-sensing global virulence regulatory system agr and the global virulence regulator sarA, the alternative sigma factor σB, alpha-hemolysin, and V8 serine protease, are required for full pathogenicity in nematodes. In addition, several defined C. elegans mutants were examined for susceptibility to S. aureus infection. Enhanced susceptibility to S. aureus killing was observed with loss-of-function mutations in the C. elegans genes esp-2/sek-1 and esp-8/nsy-1, which encode components of a conserved p38 MAP kinase signaling pathway involved in nematode defense against multiple pathogens. These results suggest that key aspects of S. aureus pathogenesis have been conserved, irrespective of the host, and that specific C. elegans host factors can alter susceptibility to this gram-positive human pathogen.
Keyword Immunology
Infectious Diseases
Infectious Diseases
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Mater Research Institute-UQ (MRI-UQ)
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Citation counts: TR Web of Science Citation Count  Cited 180 times in Thomson Reuters Web of Science Article | Citations
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