DAF-16-dependent suppression of immunity during reproduction in Caenorhabditis elegans

Miyata, Sachiko, Begun, Jakob, Troemel, Emily R. and Ausubel, Frederick M. (2008) DAF-16-dependent suppression of immunity during reproduction in Caenorhabditis elegans. Genetics, 178 2: 903-918. doi:10.1534/genetics.107.083923

Author Miyata, Sachiko
Begun, Jakob
Troemel, Emily R.
Ausubel, Frederick M.
Title DAF-16-dependent suppression of immunity during reproduction in Caenorhabditis elegans
Journal name Genetics   Check publisher's open access policy
ISSN 0016-6731
Publication date 2008-01-01
Year available 2008
Sub-type Article (original research)
DOI 10.1534/genetics.107.083923
Open Access Status DOI
Volume 178
Issue 2
Start page 903
End page 918
Total pages 16
Place of publication Bethesda, United States
Publisher Genetics Society of America
Language eng
Subject 1311 Genetics
2716 Genetics (clinical)
Formatted abstract
To further understand how the nematode Caenorhabditis elegans defends itself against pathogen attack, we analyzed enhanced pathogen resistance (epr) mutants obtained from a forward genetic screen. We also examined several well-characterized sterile mutants that exhibit an Epr phenotype. We found that sterility and pathogen resistance are highly correlated and that resistance in both epr and sterile mutants is dependent on DAF-16 activity. Our data indicate that a DAF-16-dependent signaling pathway distinct from previously described pathways is involved in the activation of genes that confer resistance to bacterial pathogens. The timing of DAF-16-dependent gene activation in sterile mutants coincides with the onset of embryonic development in wild-type animals, suggesting that signals from developing embryos normally downregulate the immune response.
Keyword Genetics & Heredity
Genetics & Heredity
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID R01 AI064332
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Mater Research Institute-UQ (MRI-UQ)
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Created: Wed, 24 Sep 2014, 20:09:14 EST by Ms Kate Rowe on behalf of Mater Research Institute-UQ