Autophagy at the crossroads of metabolism and cellular defense

Begun, Jakob and Xavier, Ramnik J. (2013) Autophagy at the crossroads of metabolism and cellular defense. Current Opinion in Gastroenterology, 29 6: 588-596. doi:10.1097/MOG.0b013e328365d34d


Author Begun, Jakob
Xavier, Ramnik J.
Title Autophagy at the crossroads of metabolism and cellular defense
Journal name Current Opinion in Gastroenterology   Check publisher's open access policy
ISSN 0267-1379
1531-7056
Publication date 2013-11-01
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1097/MOG.0b013e328365d34d
Open Access Status
Volume 29
Issue 6
Start page 588
End page 596
Total pages 9
Place of publication Philadelphia United States
Publisher Lippincott Williams & Wilkins
Language eng
Subject 2715 Gastroenterology
Formatted abstract
Purpose of Review:
From its initial description as a homeostatic process required for starvation response, autophagy has emerged as a ubiquitous cellular process involved in a broad range of cellular activities from metabolic adaptation to cellular defense against invading pathogens. This review provides an overview of autophagy and highlights the recent developments in deciphering its role in metabolic adaptation and its importance in antibacterial defense with attention to regulatory pathways.

Recent Findings:
Within the last 2 years, there has been significant progress in deciphering the mechanisms by which autophagy is regulated, including subcellular localization, posttranslational modifications, and transcriptional control. In addition, the cell type-specific role of autophagy in maintaining cellular homeostasis has been defined, including its role in handling intracellular pathogens and its contribution to inflammatory bowel disease.

Summary:
Autophagy is a critical pathway that integrates numerous regulatory inputs to maintain cellular homeostasis and defend against intracellular pathogens.
Keyword Autophagy
Bacteria
Inflammatory bowel disease
Metabolism
mTOR
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID DK043351
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Mater Research Institute-UQ (MRI-UQ)
 
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Created: Wed, 24 Sep 2014, 19:58:47 EST by Ms Kate Rowe on behalf of Mater Research Institute-UQ