Targeting the mannose receptor with mannosylated subunit vaccines

Sedaghat, B., Stephenson, R. and Toth, I. (2014) Targeting the mannose receptor with mannosylated subunit vaccines. Current Medicinal Chemistry, 21 30: 3405-3418. doi:10.2174/0929867321666140826115552

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Author Sedaghat, B.
Stephenson, R.
Toth, I.
Title Targeting the mannose receptor with mannosylated subunit vaccines
Journal name Current Medicinal Chemistry   Check publisher's open access policy
ISSN 0929-8673
Publication date 2014-10-01
Sub-type Article (original research)
DOI 10.2174/0929867321666140826115552
Volume 21
Issue 30
Start page 3405
End page 3418
Total pages 14
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Language eng
Formatted abstract
The mannose receptor (MR) is an important component of the immune system and understanding the structural and conformational characteristics of this receptor is a key aspect of vaccine design. Improved understanding of the role of carbohydrate recognition domains 4-7 (CRDs 4-7) in recognising glycosylated ligands present on the surface of pathogens such as C.albicans, P. carinii, L. donovani, and M. tuberculosis has given new insight into MR vaccine development. Initial studies identified mannan and its derivatives to be important ligands in MR targeting, providing essential knowledge about the MR structural properties. The MR was found to be an early responder in immunogenic pathways. Many attempts have been made to mimic the structural properties of yeast mannan by attaching mannan or mannose to antigenic proteins or peptide epitopes. However, a more detailed understanding of the structural properties of the MR is necessary for the design of targeted vaccines. This review describes the structure of the MR and provides an overview of the use of mannosylated proteins and peptides for vaccine targeting.
Keyword Dendritic cells
Mannose receptor
Peptide vaccine
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Chemistry and Molecular Biosciences
School of Pharmacy Publications
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 19 Sep 2014, 20:41:38 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences