Genetic architecture of subcortical brain regions: common and region-specific genetic contributions

Rentería, M. E., Hansell, N. K., Strike, L. T., McMahon, K. L., de Zubicaray, G. I., Hickie, Ian B., Thompson, Paul M., Martin, N. G., Medland, S. E. and Wright, M. J. (2014) Genetic architecture of subcortical brain regions: common and region-specific genetic contributions. Genes, Brain and Behavior, 13 8: 821-830. doi:10.1111/gbb.12177

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Author Rentería, M. E.
Hansell, N. K.
Strike, L. T.
McMahon, K. L.
de Zubicaray, G. I.
Hickie, Ian B.
Thompson, Paul M.
Martin, N. G.
Medland, S. E.
Wright, M. J.
Title Genetic architecture of subcortical brain regions: common and region-specific genetic contributions
Journal name Genes, Brain and Behavior   Check publisher's open access policy
ISSN 1601-1848
1601-183X
Publication date 2014-11-01
Sub-type Article (original research)
DOI 10.1111/gbb.12177
Open Access Status File (Author Post-print)
Volume 13
Issue 8
Start page 821
End page 830
Total pages 10
Place of publication Malden, MA, United States
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
Understanding the etiology of patterns of variation within and covariation across brain regions is key to advancing our understanding of the functional, anatomical and developmental networks of the brain. Here we applied multivariate twin modeling and principal component analysis (PCA) to investigate the genetic architecture of the size of seven subcortical regions (caudate nucleus, thalamus, putamen, pallidum, hippocampus, amygdala and nucleus accumbens) in a genetically informative sample of adolescents and young adults (N = 1,038; mean age = 21.6 ± 3.2 years; including 148 monozygotic and 202 dizygotic twin pairs) from the Queensland Twin IMaging (QTIM) Study. Our multivariate twin modeling identified a common genetic factor that accounts for all the heritability of intracranial volume (0.88) and a substantial proportion of the heritability of all subcortical structures, particularly those of the thalamus (0.71 out of 0.88), pallidum (0.52 out of 0.75) and putamen (0.43 out of 0.89). In addition, we also found substantial region-specific genetic contributions to the heritability of the hippocampus (0.39 out of 0.79), caudate nucleus (0.46 out of 0.78), amygdala (0.25 out of 0.45) and nucleus accumbens (0.28 out of 0.52). This provides further insight into the extent and organization of multiple genetic factors, which include developmental and general growth pathways, as well as functional specialization and maturation trajectories that influence each subcortical region.
Keyword Subcortical volumes
Twin study
Covariation
Structural MRI
Heritability
Multivariate
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 7 OCT 2014. Also known as "Genetic Architecture of Subcortical Brain Regions: Shared and Region-Specific Genetic Contributions".

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
School of Psychology Publications
Centre for Advanced Imaging Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 9 times in Scopus Article | Citations
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Created: Thu, 18 Sep 2014, 21:30:48 EST by Shona Osborne on behalf of School of Psychology