Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis C

Tillmann, Hans L., Patel, Keyur, Muir, Andrew J., Guy, Cynthia D., Li, Josephine H., Lao, Xiang Qian, Thompson, Alexander, Clark, Paul J., Gardner, Stephen D., McHutchison, John G. and McCarthy, Jeanette J. (2011) Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis C. Journal of Hepatology, 55 6: 1195-1200. doi:10.1016/j.jhep.2011.03.015


Author Tillmann, Hans L.
Patel, Keyur
Muir, Andrew J.
Guy, Cynthia D.
Li, Josephine H.
Lao, Xiang Qian
Thompson, Alexander
Clark, Paul J.
Gardner, Stephen D.
McHutchison, John G.
McCarthy, Jeanette J.
Title Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis C
Journal name Journal of Hepatology   Check publisher's open access policy
ISSN 0168-8278
1600-0641
Publication date 2011-12-01
Year available 2011
Sub-type Article (original research)
DOI 10.1016/j.jhep.2011.03.015
Open Access Status DOI
Volume 55
Issue 6
Start page 1195
End page 1200
Total pages 6
Place of publication Amsterdam Netherlands
Publisher Elsevier BV
Language eng
Formatted abstract
Background & Aims:
IL28B polymorphisms have been associated with both treatment induced and spontaneous clearance of hepatitis C virus (HCV). We previously found that LDL cholesterol levels were higher in chronic hepatitis C (CHC) patients with the CC genotype at the rs12979860 polymorphism, located proximal to the IL28 gene. Here we analyzed the association of steatosis with IL28B genotype in treatment naïve patients with CHC.

Methods:
Two independent cohorts of 145 genotype 1 infected patients from an antifibrotic study and 180 genotype 1 patients from Duke were analyzed for the presence and severity of steatosis in relation to the rs12979860 polymorphism at the IL28B locus. TaqMan assay based genotyping classified three groups CC, CT, and TT.

Results:
CC genotype was associated with a lower prevalence of steatosis. In the antifibrotic study, steatosis was found in 47.6% (50/105) of IL28B non-CC vs. 22.5% (9/40; p = 0.008) in CC patients. Similarly, steatosis was found in 67.4% (89/132) of non-CC patients compared to only 39.6% (19/48; p = 0.001) of CC patients in the Duke cohort.

Conclusions:
IL28B CC genotype is associated with less pronounced disturbances of lipid metabolism, as reflected both in serum lipoprotein levels and hepatic steatosis, in HCV infection.
Keyword Chronic hepatitis C
Genetic
Lipids
Il28B
Steatosis
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 1 UL1 RR024128-01
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 59 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 69 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 16 Sep 2014, 22:48:10 EST by Ms Kate Rowe on behalf of School of Medicine