A mechanistic model of mismatch negativity in the ageing brain

Cooray, Gerald, Garrido, Marta I., Hyllienmark, L. and Brismar, Tom (2014) A mechanistic model of mismatch negativity in the ageing brain. Clinical Neurophysiology, 125 9: 1774-1782. doi:10.1016/j.clinph.2014.01.015


Author Cooray, Gerald
Garrido, Marta I.
Hyllienmark, L.
Brismar, Tom
Title A mechanistic model of mismatch negativity in the ageing brain
Journal name Clinical Neurophysiology   Check publisher's open access policy
ISSN 1872-8952
1388-2457
Publication date 2014-09-01
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.clinph.2014.01.015
Open Access Status Not yet assessed
Volume 125
Issue 9
Start page 1774
End page 1782
Total pages 9
Place of publication Shannon, County Clare Ireland
Publisher Elsevier Ireland
Language eng
Subject 2809 Sensory Systems
2808 Neurology
2728 Clinical Neurology
2737 Physiology (medical)
Abstract Objective: We investigated the neurophysiological mechanisms underpinning the generation of the mismatch negativity (MMN) in the ageing brain. Methods: We used dynamic causal modelling (DCM) to study connectivity models for healthy young and old subjects. MMN was elicited with an auditory odd-ball paradigm in two groups of healthy subjects with mean age 74 (n= 30) and 26 (n= 26). DCM was implemented using up to five cortical nodes. We tested models with different hierarchical complexities. Results: We showed that the network generating MMN consisted of 5 nodes that could modulate all intra- and inter-nodal connections. The inversion of this model showed that old subjects had increased input from rSTG to the rIFG (p<. 0.01) together with increased inhibition of pyramidal cells ( p<. 0.05). Furthermore, there was reduced modulation of activity within rIFG (p<. 0.02) on stimulus change. Conclusion: The age related change in MMN is due to a decline in frontal-based control mechanisms, with alterations in connectivity between temporal and frontal regions together with a dysregulation of the excitatory-inhibitory balance in the rIFG. Significance: This study provides for the first time a neurobiological explanation for the age related changes of the MMN in the ageing brain.
Formatted abstract
Objective

We investigated the neurophysiological mechanisms underpinning the generation of the mismatch negativity (MMN) in the ageing brain.

Methods

We used dynamic causal modelling (DCM) to study connectivity models for healthy young and old subjects. MMN was elicited with an auditory odd-ball paradigm in two groups of healthy subjects with mean age 74 (n = 30) and 26 (n = 26). DCM was implemented using up to five cortical nodes. We tested models with different hierarchical complexities.

Results

We showed that the network generating MMN consisted of 5 nodes that could modulate all intra- and inter-nodal connections. The inversion of this model showed that old subjects had increased input from rSTG to the rIFG (p < 0.01) together with increased inhibition of pyramidal cells (p < 0.05). Furthermore, there was reduced modulation of activity within rIFG (p < 0.02) on stimulus change.

Conclusion

The age related change in MMN is due to a decline in frontal-based control mechanisms, with alterations in connectivity between temporal and frontal regions together with a dysregulation of the excitatory–inhibitory balance in the rIFG.

Significance

This study provides for the first time a neurobiological explanation for the age related changes of the MMN in the ageing brain.
Keyword Mismatch negativity
Dynamic causal modelling
EEG
ERP
Ageing
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2015 Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
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