Heritability of head motion during resting state functional MRI in 462 healthy twins

Couvy-Duchesne, Baptiste, Blokland, Gabriëlla A.M., Hickie, Ian B., Thompson, Paul M., Martin, Nicholas G., de Zubicaray, Greig I., McMahon, Katie L. and Wright, Margaret J. (2014) Heritability of head motion during resting state functional MRI in 462 healthy twins. Neuroimage, 102 2: 424-434. doi:10.1016/j.neuroimage.2014.08.010

Author Couvy-Duchesne, Baptiste
Blokland, Gabriëlla A.M.
Hickie, Ian B.
Thompson, Paul M.
Martin, Nicholas G.
de Zubicaray, Greig I.
McMahon, Katie L.
Wright, Margaret J.
Title Heritability of head motion during resting state functional MRI in 462 healthy twins
Journal name Neuroimage   Check publisher's open access policy
ISSN 1053-8119
Publication date 2014-01-01
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.neuroimage.2014.08.010
Volume 102
Issue 2
Start page 424
End page 434
Total pages 11
Place of publication Amsterdam, The Netherlands
Publisher Elsevier BV
Language eng
Formatted abstract
Head motion (HM) is a critical confounding factor in functional MRI. Here we investigate whether HM during resting state functional MRI (RS-fMRI) is influenced by genetic factors in a sample of 462 twins (65% fema≤ 101 MZ (monozygotic) and 130 DZ (dizygotic) twin pairs; mean age: 21 (SD=3.16), range 16-29). Heritability estimates for three HM components-mean translation (MT), maximum translation (MAXT) and mean rotation (MR)-ranged from 37 to 51%. We detected a significant common genetic influence on HM variability, with about two-thirds (genetic correlations range 0.76-1.00) of the variance shared between MR, MT and MAXT. A composite metric (HM-PC1), which aggregated these three, was also moderately heritable (h2=42%). Using a sub-sample (N=35) of the twins we confirmed that mean and maximum translational and rotational motions were consistent "traits" over repeated scans (r=0.53-0.59); reliability was even higher for the composite metric (r=0.66). In addition, phenotypic and cross-trait cross-twin correlations between HM and resting state functional connectivities (RS-FCs) with Brodmann areas (BA) 44 and 45, in which RS-FCs were found to be moderately heritable (BA44: h2-=0.23 (sd=0.041), BA45: h2-=0.26 (sd=0.061)), indicated that HM might not represent a major bias in genetic studies using FCs. Even so, the HM effect on FC was not completely eliminated after regression. HM may be a valuable endophenotype whose relationship with brain disorders remains to be elucidated
Keyword Brocas Area
Head motion
Resting state fMRI
Twin study
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Psychology Publications
Centre for Advanced Imaging Publications
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
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Created: Fri, 29 Aug 2014, 22:19:10 EST by Shona Osborne on behalf of Centre for Advanced Imaging